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Basic information

CohesinDB ID: CDBP00420576

Locus: chr21-43018084-43019388

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, GSE120943, ENCSR153HNT

Cell type: Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 52%, "4_Tx": 43%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: CHD8, MYCN, NME2, ZFX, XBP1, WT1, ZBTB48, ZBTB33, LEO1, YY1, RELA, ATF3, MYC, SP140, GRHL3, HIF1A, ARNT, NKX2-1, GATA1, DNMT3B, PLAG1, ZNF3, ESR1, ZNF22, CTCF, RBM22, BCL11A, HSF1, BRD4, MAZ, STAG1

Target gene symbol (double-evidenced CRMs): NDUFV3,HSF2BP,RRP1B,TRAPPC10,U2AF1,AGPAT3,PKNOX1,PDE9A,SLC37A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 56

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160216, ENSG00000160218,

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Deatailed information for cohesin site CDBP00420576