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Basic information

CohesinDB ID: CDBP00420579

Locus: chr21-43024487-43026869

Data sourse: ENCSR000EFJ, ENCSR000BTU, GSE67783, GSE86191, ENCSR000HPG, GSE206145, GSE62063, ENCSR153HNT, GSE138105, GSE165895

Cell type: RPE, HCT-116, SLK, Ishikawa, Ramos, IMR-90, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 46%, "5_TxWk": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: CHD8, ARID1A, MYC, ZFX, BRD4, JUN

Target gene symbol (double-evidenced CRMs): SLC37A1,RRP1B,TSPEAR,NDUFV3,AGPAT3,TRAPPC10,PDE9A,PKNOX1,U2AF1,PDXK,HSF2BP

Function elements

Human SNPs: Cognitive_performance

Number of somatic mutations (coding): 36

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160201, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160216, ENSG00000160218, ENSG00000175894,

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Deatailed information for cohesin site CDBP00420579