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Basic information

CohesinDB ID: CDBP00420585

Locus: chr21-43033645-43034830

Data sourse: GSE67783, GSE86191, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895

Cell type: RPE, Fibroblast, HCT-116, SK-N-SH, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 75%, "4_Tx": 10%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: GLIS1, FOSL1, CHD8, SMC1A, FOXA2, TBL1X, MYCN, TOP2A, ZFX, ZNF600, XBP1, ZNF317, ZBTB48, WT1, GTF2B, FOXA1, SMAD3, SUZ12, HOXB13, ERG, PAX6, RELA, IRF2, JUNB, MYC, NFIC, SP140, GRHL3, HIF1A, LHX2, RXRA, OTX2, GATA3, ARNT, HMBOX1, TAL1, PBX3, MAX, FOS, SUPT5H, MED1, NR3C1, TEAD3, NCOA3, SCRT2, SNAI2, TP53, ESR1, NCOA1, ZNF334, ZNF140, CTCF, RBM22, TCF12, JUN, SPI1, USF1, AR, ARID2, SOX4, GATA2, ZBTB42, FLI1, BRD4, SCRT1, JUND, ZNF528, SMC3, STAG1, FOSL2

Target gene symbol (double-evidenced CRMs): PDXK,TSPEAR,PKNOX1,TRAPPC10,NDUFV3,RRP1B,HSF2BP,PDE9A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160218, ENSG00000175894,

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Deatailed information for cohesin site CDBP00420585