- Basic information
- CohesinDB ID: CDBP00420638
- Locus: chr21-43186619-43189146
-
Data sourse: ENCSR000EFJ, GSE67783, GSE86191, GSE131956, GSE116868, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, ENCSR917QNE
-
Cell type: RPE, Fibroblast, HCT-116, MB157, GBM39, IMR-90, K-562, Liver, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
57% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 39%,
"14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, E2F7, SOX2, NME2, XBP1, FOXA1, HLF, SUZ12, RXRB, ZNF28, MLL4, KDM3A, TFAP4, HDGF, ATF3, BMI1, NFIC, THRB, ZFP64, CHD7, PRDM1, RUNX3, CBFB, MXD4, ZSCAN4, TP63, ZNF736, JMJD1C, ELF1, TEAD1, BCLAF1, ETV1, SNAI2, KLF6, NFE2L2, LMO2, ESR1, OCA2, RCOR2, RBM39, USF2, CTCF, JUN, TCF12, BAF155, KLF1, EP300, MNT, SOX5, PAX8, DPF2, SOX4, E2F6, DMAP1, E2F4, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, EED, JARID2, MLX, GLIS1, POU2F2, NANOG, BRD1, CHD8, ZNF263, POU5F1, MYCN, TOP2A, ZNF239, ZNF649, BRD3, ZSCAN5D, ZBTB48, MTA2, STAT1, ZBTB17, SRF, GATAD1, DDX5, SAP130, ZNF485, TBP, HNF4G, ERG, HOXC5, PBX1, ASCL1, OGG1, ETS1, MYC, EZH1, TRIP13, SMARCA4, HOMEZ, RAD21, FOXP2, GRHL3, PROX1, RXRA, GABPA, MCRS1, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, MIER3, NR2F6, ARNTL, VDR, NR3C1, CEBPB, ZNF750, HNRNPL, STAT5B, KMT2A, CREB1, EZH2, TBL1XR1, ARHGAP35, BMPR1A, GRHL2, ZNF652, EBF3, ZNF565, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, SSRP1, GATA2, ZNF644, GATAD2B, MXD3, INTS13, SIX2, FLI1, HCFC1, ZGPAT, DRAP1, RELB, HCFC1R1, NFIL3, ZNF554, ETV5, PTBP1, RUNX1, THAP11, CTNNB1, SMC1A, BCL6, HDAC1, CEBPA, CRY1, SIN3A, ZFX, POU4F2, FIP1L1, SOX13, SMAD3, AFF4, ZNF770, ERG3, TET2, ZNF473, SP5, CBX8, TWIST1, SMARCC1, PRDM10, CREBBP, RARA, ZNF384, NFYC, TAF15, ZNF35, RUNX2, GATA4, ZNF184, GR, ARNT, NFIB, NRF1, DAXX, PBX4, ZNF48, PRDM9, SMAD4, PBX3, NCAPH2, FOS, CHD1, SMARCB1, HMGXB4, MED1, TEAD3, TERF1, ZEB1, MYB, SCRT2, PIAS1, ZNF3, KLF9, NCOA1, L3MBTL2, C11orf30, STAT5A, ZNF22, TRIM28, BCL11A, SP1, TFAP2A, HNF4A, IKZF5, ARID1A, ZBTB7A, ZHX1, ASH2L, HNRNPLL, TCF3, BCOR, FOXP1, PRDM6, AATF, SMC3, ELL2, NCOR2, STAG1, STAG2, ETV4, SKI, TRP47, ZNF283, MEF2B, PPARG, FOXA2, AGO1, EBF1, CHD2, NFATC1, CREM, MIER2, GTF2B, WT1, ZNF30, ESR2, FOXF1, ZNF662, ZBTB33, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, BRCA1, SP140, ZIC2, HIF1A, TCF4, ZNF311, GATA3, TAL1, MAX, SPIB, ZNF143, AGO2, NRIP1, HAND2, PLAG1, TLE3, CEBPG, CBX2, KLF4, NCOA3, NR2F2, SP7, NEUROG2, NR2F1, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, NFKB1, MYOD1, BRD2, ELF3, KAT8, ARRB1, PHF5A, T, BHLHE40, AR, ARID4B, NFKBIZ, ZBTB40, RXR, ZBTB42, HEXIM1, RB1, TFIIIC, HSF1, ZBTB26, RNF2, BRD4, SCRT1, JUND, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): TFF1,PFKL,WDR4,AGPAT3,NDUFV3,SLC37A1,PKNOX1,PDXK,TRAPPC10,CFAP410,PDE9A,HSF2BP,TFF2,TMPRSS3,TRPM2,CBS,ABCG1,CSTB,RRP1B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 15
- Related genes and loops
- Related gene:
ENSG00000160179,
ENSG00000160181,
ENSG00000160182,
ENSG00000160183,
ENSG00000160190,
ENSG00000160191,
ENSG00000160193,
ENSG00000160194,
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160208,
ENSG00000160209,
ENSG00000160213,
ENSG00000160216,
ENSG00000160218,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
- Related loop:
chr21:42275000-42300000~~chr21:43175000-43200000,
chr21:42350000-42375000~~chr21:43175000-43200000,
chr21:42550000-42575000~~chr21:43175000-43200000,
chr21:42575000-42600000~~chr21:43175000-43200000,
chr21:42600000-42625000~~chr21:43175000-43200000,
chr21:42625000-42650000~~chr21:43175000-43200000,
chr21:42650000-42675000~~chr21:43175000-43200000,
chr21:42725000-42750000~~chr21:43175000-43200000,
chr21:42750000-42775000~~chr21:43175000-43200000,
chr21:42775000-42800000~~chr21:43175000-43200000,
chr21:42800000-42825000~~chr21:43175000-43200000,
chr21:42850000-42875000~~chr21:43175000-43200000,
chr21:42875000-42900000~~chr21:43175000-43200000,
chr21:42900000-42925000~~chr21:43175000-43200000,
chr21:42925000-42950000~~chr21:43175000-43200000,
chr21:42950000-42975000~~chr21:43175000-43200000,
chr21:43000000-43025000~~chr21:43175000-43200000,
chr21:43025000-43050000~~chr21:43175000-43200000,
chr21:43175000-43200000~~chr21:43275000-43300000,
chr21:43175000-43200000~~chr21:43300000-43325000,
chr21:43175000-43200000~~chr21:43325000-43350000,
chr21:43175000-43200000~~chr21:43350000-43375000,
chr21:43175000-43200000~~chr21:43575000-43600000,
chr21:43175000-43200000~~chr21:43600000-43625000,
chr21:43175000-43200000~~chr21:43625000-43650000,
chr21:43175000-43200000~~chr21:43650000-43675000,
chr21:43175000-43200000~~chr21:43725000-43750000,
chr21:43175000-43200000~~chr21:43750000-43775000,
chr21:43175000-43200000~~chr21:43850000-43875000,
chr21:43175000-43200000~~chr21:43875000-43900000,
chr21:43175000-43200000~~chr21:43950000-43975000,
chr21:43175000-43200000~~chr21:43975000-44000000,
chr21:43175000-43200000~~chr21:44025000-44050000,
chr21:43175000-43200000~~chr21:44050000-44075000,
chr21:43175000-43200000~~chr21:44075000-44100000,
chr21:43175000-43200000~~chr21:44275000-44300000,
chr21:43175000-43200000~~chr21:44375000-44400000,
chr21:6075000-6100000~~chr21:43175000-43200000,
chr21:6100000-6125000~~chr21:43175000-43200000,
chr21:6125000-6150000~~chr21:43175000-43200000,
chr21:6550000-6575000~~chr21:43175000-43200000,