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Basic information

CohesinDB ID: CDBP00420639

Locus: chr21-43189488-43189736

Data sourse: GSE67783, ENCSR153HNT

Cell type: K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 43%, "14_ReprPCWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, E2F7, SOX2, NME2, XBP1, FOXA1, HLF, SUZ12, RXRB, ZNF28, MLL4, KDM3A, TFAP4, HDGF, ATF3, BMI1, NFIC, THRB, ZFP64, CHD7, PRDM1, RUNX3, CBFB, MXD4, ZSCAN4, TP63, ZNF736, JMJD1C, ELF1, TEAD1, BCLAF1, ETV1, SNAI2, KLF6, NFE2L2, LMO2, ESR1, OCA2, RCOR2, RBM39, USF2, CTCF, JUN, TCF12, BAF155, KLF1, EP300, MNT, SOX5, PAX8, DPF2, SOX4, E2F6, DMAP1, E2F4, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, EED, JARID2, MLX, GLIS1, POU2F2, NANOG, BRD1, CHD8, ZNF263, POU5F1, MYCN, TOP2A, ZNF239, ZNF649, BRD3, ZSCAN5D, ZBTB48, MTA2, STAT1, ZBTB17, SRF, GATAD1, DDX5, SAP130, ZNF485, TBP, HNF4G, ERG, HOXC5, PBX1, ASCL1, OGG1, ETS1, MYC, EZH1, TRIP13, SMARCA4, HOMEZ, RAD21, FOXP2, GRHL3, PROX1, RXRA, GABPA, MCRS1, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, MIER3, NR2F6, ARNTL, VDR, NR3C1, CEBPB, ZNF750, HNRNPL, STAT5B, KMT2A, CREB1, EZH2, TBL1XR1, ARHGAP35, BMPR1A, GRHL2, ZNF652, EBF3, ZNF565, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, SSRP1, GATA2, ZNF644, GATAD2B, MXD3, INTS13, SIX2, FLI1, HCFC1, ZGPAT, DRAP1, RELB, HCFC1R1, NFIL3, ZNF554, ETV5, PTBP1, RUNX1, THAP11, CTNNB1, SMC1A, BCL6, HDAC1, CEBPA, CRY1, SIN3A, ZFX, POU4F2, FIP1L1, SOX13, SMAD3, AFF4, ZNF770, ERG3, TET2, ZNF473, SP5, CBX8, TWIST1, SMARCC1, PRDM10, CREBBP, RARA, ZNF384, NFYC, TAF15, ZNF35, RUNX2, GATA4, ZNF184, GR, ARNT, NFIB, NRF1, DAXX, PBX4, ZNF48, PRDM9, SMAD4, PBX3, NCAPH2, FOS, CHD1, SMARCB1, HMGXB4, MED1, TEAD3, TERF1, ZEB1, MYB, SCRT2, PIAS1, ZNF3, KLF9, NCOA1, L3MBTL2, C11orf30, STAT5A, ZNF22, TRIM28, BCL11A, SP1, TFAP2A, HNF4A, IKZF5, ARID1A, ZBTB7A, ZHX1, ASH2L, HNRNPLL, TCF3, BCOR, FOXP1, PRDM6, AATF, SMC3, ELL2, NCOR2, STAG1, STAG2, ETV4, SKI, TRP47, ZNF283, MEF2B, PPARG, FOXA2, AGO1, EBF1, CHD2, NFATC1, CREM, MIER2, GTF2B, WT1, ZNF30, ESR2, FOXF1, ZNF662, ZBTB33, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, BRCA1, SP140, ZIC2, HIF1A, TCF4, ZNF311, GATA3, TAL1, MAX, SPIB, ZNF143, AGO2, NRIP1, HAND2, PLAG1, TLE3, CEBPG, CBX2, KLF4, NCOA3, NR2F2, SP7, NEUROG2, NR2F1, KDM5B, TP53, PKNOX1, ZNF687, ZNF334, NFKB1, MYOD1, BRD2, ELF3, KAT8, ARRB1, PHF5A, T, BHLHE40, AR, ARID4B, NFKBIZ, ZBTB40, RXR, ZBTB42, HEXIM1, RB1, TFIIIC, HSF1, ZBTB26, RNF2, BRD4, SCRT1, JUND, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TRAPPC10,TMPRSS3,CBS,AGPAT3,HSF2BP,TRPM2,PDXK,TFF2,CFAP410,CSTB,PFKL,RRP1B,ABCG1,SLC37A1,WDR4,TFF1,PDE9A,PKNOX1,NDUFV3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185,

eachgene

Deatailed information for cohesin site CDBP00420639