Browse_each

Basic information

CohesinDB ID: CDBP00420647

Locus: chr21-43208557-43212285

Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE25021, GSE115250, GSE76893, GSE145327, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR153HNT, GSE68388, GSE126990

Cell type: RH4, GM2610, CVB-hiPSC, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, Kelly, HeLa-S3, IMR-90, BCBL-1, K-562, DKO, HFFc6, GM18526, H1-hESC, GM18951, Monocytes, MB157, Lymphoblast, GM12878, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, HeLa, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 37% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.511

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 57% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 38%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, TRIM25, HMG20A, XBP1, FOXA1, RBFOX2, RXRB, SMAD1-5, PBX2, ZFHX2, KDM3A, TFAP4, SIN3B, ATF3, THRB, NFIC, ZFP64, CTCFL, MORC2, CBFB, MXD4, MECOM, TP63, KLF5, ELF1, TEAD1, TRIM28, KLF6, RBM39, NFE2L2, KLF10, RCOR2, ESR1, OCA2, USF2, CTCF, TCF12, JUN, EP300, KLF1, MNT, GATA6, SOX5, SOX4, E2F6, DMAP1, RFX5, DEK, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, EED, RBPJ, MLX, GLIS1, POU2F2, CHD8, BRD1, MYCN, POU5F1, TOP2A, BRD3, SRC, RUNX1T1, ZNF317, ZNF263, ZBTB48, ZSCAN5A, STAT1, NONO, MLLT3, GATAD1, SAP130, SRF, ARID3A, GMEB2, SP4, TBP, HNF4G, ERG, HOXC5, ASCL1, OGG1, SMARCC2, ETS1, MYC, KDM4A, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, MCRS1, STAT3, XRCC5, ZNF614, PRDM14, RCOR1, DNMT3B, NR2F6, MIER3, VDR, ARNTL, NR3C1, CEBPB, ESRRA, HNRNPL, CREB1, EZH2, TBL1XR1, GRHL2, ZNF652, GABPB1, ZHX2, TFE3, MIXL1, HBP1, IRF1, ZNF257, HDAC2, GATA2, ZNF644, MXD3, SREBF1, FLI1, DRAP1, ZGPAT, MXI1, NFIL3, NCOA2, PTBP1, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, SIRT6, FIP1L1, ZFX, AFF4, SIN3A, SOX13, SMAD3, ZNF534, POU4F2, TET2, ERG3, TBX3, SP5, SMARCC1, CREBBP, RARA, ZBTB2, NFYC, TAF15, RUNX2, CDK6, GATA4, PBX4, NRF1, DAXX, ARNT, ZNF48, PRDM9, SMAD4, PBX3, FOXM1, FOS, SMARCB1, CHD1, HMGXB4, CDK8, MED1, TEAD3, SPDEF, CEBPD, ZMYM3, SMAD1, U2AF1, ZNF3, NR1H2, KLF9, SREBF2, MBD1, USF1, SP1, MAFK, NIPBL, HNF4A, IKZF5, REST, ZBTB7A, ZHX1, ASH2L, HNRNPLL, FOXP1, AATF, SMC3, ELL2, STAG1, STAG2, ETV4, SKI, NELFA, TRP47, PPARG, FOXA2, AGO1, CREM, CHD2, MIER2, ZNF600, GTF2B, WT1, MAFF, ESR2, ZBTB33, ZNF580, ZKSCAN1, KLF7, KDM1A, YY1, RELA, JUNB, MCM3, SP140, ZIC2, HIF1A, ZFP36, GATA3, MAX, NRIP1, ZNF143, PLAG1, CEBPG, KLF4, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, ZNF334, NFKB1, ELF3, BRD2, KAT8, PHF5A, ARID4B, AR, BHLHE40, TAF1, NFKBIZ, YAP1, RXR, EGLN2, ZNF366, EGR1, HEXIM1, HSF1, ZBTB26, RNF2, BRD4, JUND, CLOCK, CUX1, MAZ, BRCA1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TMPRSS3,TRAPPC10,TFF1,DNMT3L,TMPRSS2,TRPM2,CSTB,PKNOX1,HSF2BP,WDR4,PDXK,PDE9A,TFF2,MX2,NDUFV3,RRP1B

Function elements

Human SNPs: Male-pattern_baldness

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 14

Related genes and loops

Related gene: ENSG00000183486, ENSG00000184012, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160191, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160218, ENSG00000142182, ENSG00000142185,

eachgene

Deatailed information for cohesin site CDBP00420647