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Basic information

CohesinDB ID: CDBP00420650

Locus: chr21-43265406-43280154

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE152721, GSE51234, GSE120943, ENCSR198ZYJ, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE93080, GSE94872, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, GSE206145, GSE97394, GSE55407, ENCSR000BTQ, GSE38395, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, TC-71, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 38% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.322

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 24%, "15_Quies": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, ZNF195, ZNF621, XBP1, FOXA1, SUZ12, ZFHX2, ZBTB7B, ATF3, ZNF112, THAP1, ZBTB5, PRDM1, ZNF444, ZNF429, ZNF467, ZNF121, BCLAF1, TRIM28, LMO2, ESR1, OCA2, ZNF571, ZIK1, CTCF, TCF12, ZNF695, GLI4, DEK, ZNF512B, ZNF776, ZNF528, ZNF175, EHMT2, TFAP2C, YBX1, POU2F2, CHD8, NANOG, POU5F1, ZNF239, MYCN, ZNF263, TOP2A, ZNF317, ZBTB48, STAT1, ZNF488, DDX5, HIC1, ERG2, ZNF300, ERG, ETS1, RFX1, RAD21, GRHL3, BATF3, GABPA, XRCC5, ZNF398, ZNF639, ESRRA, HNRNPL, CREB1, ZNF560, EZH2, GRHL2, ZNF292, HES1, SSRP1, GATAD2B, ZNF146, ZNF785, NCOA2, SALL2, CC2D1A, AHRR, HDAC1, ZNF707, CRY1, ZFX, ZFP37, ZNF473, ERG3, CREBBP, ZNF184, ZNF280C, NFIB, SOX11, PRDM9, SMARCB1, CHD1, ZNF680, ZNF3, NCOA1, USF1, NIPBL, SP1, BCL11A, REST, ZBTB7A, HNRNPLL, SALL1, TCF3, SMC3, STAG1, ZNF394, ZNF207, MTA3, CHD2, WT1, ZNF662, ZKSCAN1, YY1, RELA, TARDBP, ZNF148, ZNF266, ZNF521, MCM3, ZNF311, MAF1, MAX, NRIP1, ZNF143, ZSCAN26, NCOA3, ZNF544, ZNF791, TCF7L2, PKNOX1, BCL6B, ZSCAN22, EGR2, ARRB1, BHLHE40, AR, ZBTB40, ZBTB26, HSF1, RNF2, ZNF248, PRDM2, BRD4, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): WDR4,PFKL,PKNOX1,SLC37A1,DNMT3L,RSPH1,HSF2BP,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 35

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160188, ENSG00000160190, ENSG00000160193, ENSG00000160199, ENSG00000160207, ENSG00000142182, ENSG00000141959,

eachgene

Deatailed information for cohesin site CDBP00420650