- Basic information
- CohesinDB ID: CDBP00420651
- Locus: chr21-43280924-43283710
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Data sourse: ENCSR000BLD, ENCSR167MTG, GSE67783, GSE72082, GSE86191, GSE98367, GSE111913, GSE76893, ENCSR000BLS, GSE105028, GSE206145-NatGen2015, ENCSR054FKH, GSE206145, GSE120943, ENCSR153HNT, GSE25021, GSE50893
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Cell type: MCF-7, GM12892, GM2630, Fibroblast, H1-hESC, HCT-116, Hep-G2, Monocytes, RPE, RT-112, K-562, HSPC, Macrophage, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
65% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 46%,
"14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, PGR, XBP1, PATZ1, FOXA1, RXRB, ZFHX2, ATF3, BMI1, RUNX3, ZNF444, CBFB, PAX5, SFPQ, JMJD1C, ELF1, BCLAF1, COBLL1, ESR1, CTCF, TCF12, LMO1, DPF2, PAX8, ZNF512B, ZNF528, GTF2F1, EHMT2, TFAP2C, EED, YBX1, POU2F2, BRD1, MYCN, ZNF263, TOP2A, CTBP1, MTA2, ZBTB17, ZBTB48, ZBTB1, STAT1, ZSCAN21, DUX4, ERG2, SP4, ZNF300, ERG, OGG1, MYC, SMARCA4, RFX1, RAD21, GRHL3, FOXK2, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, DNMT3B, ZNF639, NFE2, NR3C1, ESRRA, ZNF750, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, ZHX2, PCBP1, HDAC2, ZNF644, GATAD2B, MXD3, ETV5, RUNX1, SMC1A, HDAC1, ZFX, POU4F2, ZNF747, TET2, ERG3, RARA, ZBTB2, CDK6, ZNF184, ARNT, NFIB, ZBTB10, ZNF48, ATF2, SMAD4, SMARCB1, CDK8, TEAD3, MYB, KLF9, USF1, SP1, ZBTB7A, ZHX1, ATF7, HNRNPLL, TCF3, GLIS2, AATF, SMC3, STAG1, MLLT1, TRP47, MEF2B, PPARG, FOXA2, ZNF207, EBF1, NFATC1, ZNF600, WT1, ZNF662, BCL3, ZKSCAN1, YY1, RELA, TARDBP, ZIC2, ZNF311, ZNF143, GATA1, PLAG1, ZNF141, NCOA3, NR2F1, TP53, PKNOX1, EGR2, ZNF140, PHOX2B, BHLHE40, AR, RXR, EGLN2, ZBTB42, HEXIM1, RB1, ZNF366, HSF1, ZBTB26, BRD4, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): HSF2BP,DNMT3L,PFKL,ABCG1,PKNOX1,WDR4
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000160179,
ENSG00000160193,
ENSG00000160199,
ENSG00000160207,
ENSG00000142182,
ENSG00000141959,
- Related loop:
chr21:28775000-28800000~~chr21:43275000-43300000,
chr21:42300000-42325000~~chr21:43275000-43300000,
chr21:42850000-42875000~~chr21:43275000-43300000,
chr21:42950000-42975000~~chr21:43275000-43300000,
chr21:43000000-43025000~~chr21:43275000-43300000,
chr21:43175000-43200000~~chr21:43275000-43300000,
chr21:43275000-43300000~~chr21:43600000-43625000,
chr21:43275000-43300000~~chr21:43625000-43650000,
chr21:43275000-43300000~~chr21:44250000-44275000,
chr21:43275000-43300000~~chr21:44275000-44300000,
chr21:6025000-6050000~~chr21:43275000-43300000,
chr21:6550000-6575000~~chr21:43275000-43300000,