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Basic information

CohesinDB ID: CDBP00420652

Locus: chr21-43285633-43286421

Data sourse: GSE67783, GSE86191, GSE111913, GSE206145-NatGen2015, ENCSR153HNT, GSE116344

Cell type: Fibroblast, RH4, HCT-116, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 62%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, PGR, XBP1, PATZ1, FOXA1, RXRB, ZFHX2, ATF3, BMI1, RUNX3, ZNF444, CBFB, PAX5, SFPQ, JMJD1C, ELF1, BCLAF1, COBLL1, ESR1, CTCF, TCF12, LMO1, DPF2, PAX8, ZNF512B, ZNF528, GTF2F1, EHMT2, TFAP2C, EED, YBX1, POU2F2, BRD1, MYCN, ZNF263, TOP2A, CTBP1, MTA2, ZBTB17, ZBTB48, ZBTB1, STAT1, ZSCAN21, DUX4, ERG2, SP4, ZNF300, ERG, OGG1, MYC, SMARCA4, RFX1, RAD21, GRHL3, FOXK2, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, DNMT3B, ZNF639, NFE2, NR3C1, ESRRA, ZNF750, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, ZHX2, PCBP1, HDAC2, ZNF644, GATAD2B, MXD3, ETV5, RUNX1, SMC1A, HDAC1, ZFX, POU4F2, ZNF747, TET2, ERG3, RARA, ZBTB2, CDK6, ZNF184, ARNT, NFIB, ZBTB10, ZNF48, ATF2, SMAD4, SMARCB1, CDK8, TEAD3, MYB, KLF9, USF1, SP1, ZBTB7A, ZHX1, ATF7, HNRNPLL, TCF3, GLIS2, AATF, SMC3, STAG1, MLLT1, TRP47, MEF2B, PPARG, FOXA2, ZNF207, EBF1, NFATC1, ZNF600, WT1, ZNF662, BCL3, ZKSCAN1, YY1, RELA, TARDBP, ZIC2, ZNF311, ZNF143, GATA1, PLAG1, ZNF141, NCOA3, NR2F1, TP53, PKNOX1, EGR2, ZNF140, PHOX2B, BHLHE40, AR, RXR, EGLN2, ZBTB42, HEXIM1, RB1, ZNF366, HSF1, ZBTB26, BRD4, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): DNMT3L,ABCG1,PFKL,WDR4,PKNOX1,HSF2BP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160193, ENSG00000160199, ENSG00000160207, ENSG00000142182, ENSG00000141959,

eachgene

Deatailed information for cohesin site CDBP00420652