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Basic information

CohesinDB ID: CDBP00420654

Locus: chr21-43290025-43293553

Data sourse: ENCSR000BLD, GSE93080, GSE206145-GSE177045, ENCSR000EAC, ENCSR000DZP, GSE143937, ENCSR000BKV, GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, GSE62063, ENCSR153HNT, GSE83726, GSE116344, GSE50893

Cell type: MCF-7, GM2630, H1-hESC, Fibroblast, HCT-116, RH4, RPE, GM12878, K-562, HSPC, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 42%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, MORC2, PAX5, TEAD1, LMO2, OCA2, E4F1, ARID5B, SOX5, ZNF211, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, SMARCA4, RFX1, ZNF398, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, TBX3, SP5, SMARCC1, ZXDC, SMARCB1, PIAS1, C11orf30, STAT5A, IKZF5, MBD2, ELL2, NFATC3, CBFA2T2, MEF2B, CREM, NFATC1, WT1, JUNB, TCF4, BATF, SPIB, PLAG1, KLF4, BCL11B, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, NCOR1, ZBTB26, ZNF316, FOSL1, XBP1, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, TP63, MITF, MYOG, JMJD1C, ELF1, ZNF573, SNAI2, CTCF, JUN, LMO1, MNT, DPF2, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB48, DDX5, PBX1, ONECUT1, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, GRHL2, EBF3, NFIL3, THAP11, EZH2phosphoT487, AFF4, SOX13, ZNF770, DAXX, ARNT, BACH1, ZNF48, PRDM9, PBX3, MAFB, NCAPH2, HMGXB4, TEAD3, DIDO1, U2AF1, KLF9, USF1, SP1, TFAP2A, BCL11A, ATF7, ASH2L, CTBP2, SMC3, STAG1, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, KDM1A, BRG1, GATA3, TAL1, NRIP1, ZNF143, MTA1, ZNF141, TP53, ZNF334, PHF5A, KAT8, ARRB1, EGR1, TFIIIC, IKZF2, BRD4, JUND, PGR, PATZ1, UBTF, TFAP4, CHD7, ATF4, MXD4, KLF6, NFE2L2, ESR1, E2F6, TRIM24, RFX5, GTF2F1, POU2F2, ZSCAN5D, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, EZH2, SPI1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, RARA, ZNF384, NFYC, ZNF169, SMAD4, ZNF518A, CDK8, ZEB1, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TCF7, ZNF318, RELA, TARDBP, MAX, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, HEXIM1, ZNF280D, DMAP1, AHR, MBD3, FOSL2, HMG20A, SUZ12, RBFOX2, ZFHX2, CTCFL, PRDM1, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, SOX6, RAD51, E2F1, TEAD4, FOXA3, ZNF175, EHMT2, EED, MYCN, CDK7, RUNX1T1, GATAD1, ARID3A, ASCL1, MIER1, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF750, HES1, TFE3, IRF1, SREBF1, ZGPAT, ATF1, PTBP1, SMC1A, MAFG, CBX1, SIRT6, ZFX, ZNF534, SMAD3, PCBP2, TWIST1, PRPF4, NOTCH1, RUNX2, GATA4, GR, PBX4, FOS, CHD1, MED1, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, TCF3, SKI, FOXA2, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, BHLHE22, GATA1, HAND2, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, ZBTB40, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): HSF2BP,PKNOX1,ABCG1,DNMT3L,PFKL,WDR4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 23

Related genes and loops

Related gene: ENSG00000160179, ENSG00000160193, ENSG00000160199, ENSG00000160207, ENSG00000142182, ENSG00000141959,

eachgene

Deatailed information for cohesin site CDBP00420654