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Basic information

CohesinDB ID: CDBP00420657

Locus: chr21-43296982-43309547

Data sourse: ENCSR000BLD, GSE72082, GSE116868, ENCSR150EFU, ENCSR000ECS, GSE103477, GSE131606, GSE108869, GSE25021, GSE165895, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, ShirahigeLab-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR703TNG, GSE116344, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR193NSH, ENCSR000BLS, ShirahigeLab, GSE85526, ENCSR247LSH, ENCSR620NWG, ENCSR217ELF, GSE38395, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE129526, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR748MVX, GSE38411

Cell type: RH4, GM2610, HuCC-T1, RPE, Fibroblast, HEKn, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, Monocytes, MB157, GM12878, GM2588, RT-112, HeLa-Tet-On, THP-1, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 21% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.622

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 26%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, THAP1, ZBTB44, PAX5, TEAD1, LMO2, OCA2, MED26, HDAC8, SOX5, PAX8, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, HHEX, BRD3, CTBP1, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB21, ZNF597, NFKB2, SMARCA4, ZNF8, ZNF398, RCOR1, NR2F6, CD74, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, DRAP1, MXI1, RELB, HCFC1R1, RUNX1, CEBPA, NKX2-2, CRY1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, SMAD1, C11orf30, MBD1, STAT5A, IKZF5, ZNF605, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, NFATC1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, ZNF311, BATF, SPIB, PLAG1, ZFP69B, KLF4, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, CDK2, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, ZBTB20, DPF2, SIX5, IRF4, ZNF776, RBPJ, TFAP2C, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, DDX5, NBN, PBX1, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, CTNNB1, SOX13, AFF4, ZNF747, ZNF770, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, KLF9, TBX5, USF1, SP1, TFAP2A, BCL11A, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, CBX2, ZNF141, TP53, ZNF334, NFKB1, ZSCAN22, PHF5A, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, BRD4, TBX2, PGR, SOX2, PATZ1, UBTF, SMAD1-5, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, TP73, SND1, KLF1, ZNF695, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, ZNF24, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, ZNF652, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, MYBL2, CREBBP, RARA, NFYC, ZNF384, TAF15, ZNF169, ZNF35, SMAD4, CBFA2T3, CDK8, ZEB1, SREBF2, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, ZNF692, GTF2B, ZNF662, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, YAP1, ZNF324, RBAK, HEXIM1, ZNF280D, DMAP1, AHR, FOSL2, HMG20A, ZSCAN5C, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, PRDM1, ZNF736, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ZNF26, ETV1, RCOR2, MLL, USF2, TCF12, EP300, GATA6, GLI4, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, BRD1, MYCN, SRC, ID3, HINFP, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, ZNF750, TFE3, EHF, IRF1, ZGPAT, MYF5, PTBP1, SMC1A, MAFG, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, CBX8, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, FOS, CHD1, TGIF2, MED1, KDM6B, CEBPD, SCRT2, MYB, L3MBTL2, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, NELFA, FOXA2, RBBP5, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, BHLHE22, GATA1, HAND2, CEBPG, SP7, NR2F2, BHLHE40, NFKBIZ, ZBTB42, MYNN, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): AGPAT3,DNMT3L,HSF2BP,PKNOX1,PDE9A,WDR4,NDUFV3,TSPEAR,TRAPPC10,PFKL,CFAP410,CSTB,PDXK,SLC37A1,ABCG1,RSPH1,CBS,RRP1B,C2CD2

Function elements

Human SNPs: Medication_use_(agents_acting_on_the_renin-angiotensin_system)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 74

Related genes and loops

Related gene: ENSG00000157617, ENSG00000160179, ENSG00000160188, ENSG00000160190, ENSG00000160191, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420657