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Basic information

CohesinDB ID: CDBP00420659

Locus: chr21-43328508-43351938

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000EGW, GSE25021, ENCSR150EFU, GSE105028, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR000DYE, ENCSR000EFJ, ENCSR000BTU, ENCSR917QNE, GSE115602, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE126755, ENCSR000ECS, ENCSR481YWD

Cell type: RH4, SLK, Liver, GP5d, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, DKO, H1-hESC, Monocytes, MB157, RT-112, HeLa-Tet-On, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 49% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 34%, "5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, ZNF195, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, E4F1, SOX5, PYGO2, PAX8, DEK, E2F4, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, PAX6, SMARCA4, RFX1, TOP1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, MXI1, DRAP1, ZNF785, RELB, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, ZNF707, IRF3, TET2, ZNF473, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZXDC, ZBTB2, ELK1, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, SS18, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, MCM3, ZFP36, TCF4, ZNF311, BATF, SPIB, ZSCAN26, PLAG1, KLF4, ZFP69B, ZNF544, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ZNF316, FOSL1, ZNF621, XBP1, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, DPF1, TP63, ZSCAN4, MITF, BACH2, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF571, ZIK1, CTCF, JUN, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF776, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, YBX1, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, CHD4, ZNF329, ONECUT1, TRIP13, KDM4A, HOMEZ, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, TBL1XR1, ARHGAP35, GRHL2, ZNF565, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, SOX13, AFF4, ZNF747, ZNF770, ZNF513, ZNF18, ARNT, NFIB, DAXX, BACH1, ZNF48, PRDM9, NFYA, PBX3, NCAPH2, ETV6, MAFB, HMGXB4, TEAD3, DIDO1, ZNF680, U2AF1, KLF9, TBX5, USF1, SP1, TFAP2A, BCL11A, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAT2, STAG1, MLLT1, STAG2, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KAT2B, ZNF266, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, CBX2, ZNF141, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, PRDM2, CUX1, ZSCAN23, SMAD4.1D12, PGR, ZNF496, SOX2, PATZ1, SMAD1-5, UBTF, TFAP4, BMI1, ZNF112, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ASH1L, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, ZNF114, OGG1, SMARCC2, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, BPTF, ZNF652, MRTFA, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NCOA2, NFYB, ZNF554, ETV5, SALL2, BCL6, SIN3A, ERG3, NFXL1, MEF2A, RARA, CREBBP, ZNF384, NFYC, TAF15, HMGB2, SMAD4, CDK8, CSNK2A1, ZEB1, SPDEF, ZMYM3, NCOA1, SREBF2, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, HDAC6, ZNF692, GTF2B, ZNF662, RELA, TARDBP, ZNF611, SKIL, MGA, MAX, ZNF592, NR2F1, TCF7L2, NEUROG2, KDM5B, ZNF791, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZBTB16, YAP1, HEXIM1, AHR, FOSL2, MBD3, DMAP1, HMG20A, LCORL, E2F7, HMGN3, SUZ12, ZNF28, ZFHX2, SFMBT1, NFIC, ZBTB5, CTCFL, PRDM1, KLF14, MECOM, ZNF736, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ZNF26, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, GLI4, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, ARID3A, ZNF300, ASCL1, USP7, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ARNTL, ZNF750, TRPS1, HES1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, CBX1, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, NRF1, PBX4, CHD1, FOS, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF521, BRCA1, SP140, HIF1A, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RRP1,TRPM2,FAM3B,PFKL,AGPAT3,MX2,CBS,TFF1,NDUFV3,PDXK,RRP1B,CFAP410,UBE2G2,SUMO3,PDE9A,LRRC3,UMODL1,FAM207A,TFF2,DNMT3L,HSF2BP,TRAPPC10,ITGB2,CSTB,TMPRSS3,PKNOX1,WDR4,ADARB1,ITGB2-AS1,ABCG1

Function elements

Human SNPs: Systolic_blood_pressure

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 184

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000177398, ENSG00000160179, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160191, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000184787, ENSG00000184900, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381,

eachgene

Deatailed information for cohesin site CDBP00420659