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Basic information

CohesinDB ID: CDBP00420662

Locus: chr21-43371758-43372139

Data sourse: GSE111913, ENCSR153HNT, GSE86191

Cell type: K-562, RT-112, HCT-116

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 65% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 49%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF195, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, PAX5, ZNF320, TEAD1, LMO2, OCA2, PITX3, HDAC8, ARID5B, E4F1, SOX5, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, STAT1, ZNF563, SAP130, ERG, ZBTB8A, SMARCA4, ZNF8, RCOR1, NR2F6, CD74, CEBPB, HNRNPL, CREB1, EPAS1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, SIX2, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF707, CRY1, TET2, TBX3, ZNF473, SP5, TRIM22, SMARCC1, ZBTB2, TFDP1, SOX11, ATF2, FOXM1, SP2, SMARCB1, TERF1, EVI1, MBD1, STAT5A, IKZF5, ELL2, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, NFATC1, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, ZNF311, BATF, PLAG1, KLF4, BCL11B, MED, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, ZNF316, FOSL1, SMARCA2, XBP1, PBX2, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, LMO1, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF317, ZSCAN21, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PBX1, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, ARHGAP35, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, ZBTB24, AFF4, SOX13, POU4F2, ZNF18, ARNT, BACH1, NFIB, DAXX, ZNF48, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, KLF9, USF1, SP1, TFAP2A, BCL11A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, CBX2, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, TBX2, PGR, SOX2, PATZ1, UBTF, TFAP4, CHD7, MXD4, ZNF189, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ELK4, ERG2, TBP, HNF4G, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, NFYB, ETV5, SALL2, BCL6, SIN3A, ERG3, NFXL1, MEF2A, CREBBP, RARA, ZNF384, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, SREBF2, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, AATF, NCOR2, PPARG, GTF2B, ZNF662, YY2, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, HEXIM1, AHR, FOSL2, MBD3, HMG20A, MEIS2, SUZ12, ZFHX2, SFMBT1, ZNF90, NFIC, CTCFL, MECOM, ZNF736, ZNF629, KLF5, TRIM28, BCLAF1, RCOR2, MLL, USF2, TCF12, EP300, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, ZNF205, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF667, ZNF750, FEZF1, HES1, TFE3, EHF, IRF1, SREBF1, ZGPAT, ZNF766, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, PBX4, NRF1, NR2C1, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, ZNF558, ZNF3, L3MBTL2, KLF16, NIPBL, PHF20, ZBTB7A, POU2F3, TCF3, SKI, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, YY1, ZNF148, SP140, HIF1A, BHLHE22, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB42, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): ADARB1,TRAPPC10,RRP1,PDXK,FAM207A,ITGB2-AS1,PFKL,ABCG1,RRP1B,AGPAT3,UMODL1,DNMT3L,PDE9A,HSF2BP,CFAP410,PKNOX1,TRPM2,MX2,ITGB2,WDR4,SUMO3,UBE2G2,CSTB,LRRC3,NDUFV3,CBS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000183486, ENSG00000177398, ENSG00000160179, ENSG00000160191, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000184787, ENSG00000184900, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381,

eachgene

Deatailed information for cohesin site CDBP00420662