- Basic information
- CohesinDB ID: CDBP00420663
- Locus: chr21-43372411-43378616
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Data sourse: GSE67783, GSE86191, GSE98367, GSE138405, GSE116868, GSE111913, GSE105028, GSE101921, GSE206145-NatGen2015, GSE206145, ENCSR000EDE, ENCSR153HNT, GSE112028, GSE68388, GSE126990, GSE108869, ENCSR000ECS
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Cell type: RPE, Macrophage, Hela-Kyoto, Fibroblast, HCT-116, MB157, MCF-10A, HeLa-S3, RT-112, K-562, HeLa-Tet-On, HSPC, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
65% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 34%,
"14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF195, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, PAX5, ZNF320, TEAD1, LMO2, OCA2, PITX3, HDAC8, ARID5B, E4F1, SOX5, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, STAT1, ZNF563, SAP130, ERG, ZBTB8A, SMARCA4, ZNF8, RCOR1, NR2F6, CD74, CEBPB, HNRNPL, CREB1, EPAS1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, SIX2, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF707, CRY1, TET2, TBX3, ZNF473, SP5, TRIM22, SMARCC1, ZBTB2, TFDP1, SOX11, ATF2, FOXM1, SP2, SMARCB1, TERF1, EVI1, MBD1, STAT5A, IKZF5, ELL2, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, NFATC1, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, ZNF311, BATF, PLAG1, KLF4, BCL11B, MED, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, ZNF316, FOSL1, SMARCA2, XBP1, PBX2, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, LMO1, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF317, ZSCAN21, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PBX1, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, TBL1XR1, ARHGAP35, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, ZBTB24, AFF4, SOX13, POU4F2, ZNF18, ARNT, BACH1, NFIB, DAXX, ZNF48, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, KLF9, USF1, SP1, TFAP2A, BCL11A, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, CBX2, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, TBX2, PGR, SOX2, PATZ1, UBTF, TFAP4, CHD7, MXD4, ZNF189, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ELK4, ERG2, TBP, HNF4G, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, NFYB, ETV5, SALL2, BCL6, SIN3A, ERG3, NFXL1, MEF2A, CREBBP, RARA, ZNF384, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, SREBF2, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, AATF, NCOR2, PPARG, GTF2B, ZNF662, YY2, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, HEXIM1, AHR, FOSL2, MBD3, HMG20A, MEIS2, SUZ12, ZFHX2, SFMBT1, ZNF90, NFIC, CTCFL, MECOM, ZNF736, ZNF629, KLF5, TRIM28, BCLAF1, RCOR2, MLL, USF2, TCF12, EP300, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, ZNF205, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF667, ZNF750, FEZF1, HES1, TFE3, EHF, IRF1, SREBF1, ZGPAT, ZNF766, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, SMAD3, CBX8, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, ZNF184, PBX4, NRF1, NR2C1, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, ZNF558, ZNF3, L3MBTL2, KLF16, NIPBL, PHF20, ZBTB7A, POU2F3, TCF3, SKI, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, YY1, ZNF148, SP140, HIF1A, BHLHE22, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB42, CLOCK, MAZ, BRCA1
- Target gene symbol (double-evidenced CRMs): LRRC3,ADARB1,PDXK,TRAPPC10,CBS,ITGB2-AS1,UMODL1,RRP1,ITGB2,PFKL,CSTB,SUMO3,PKNOX1,NDUFV3,PDE9A,MX2,FAM207A,HSF2BP,TRPM2,AGPAT3,RRP1B,DNMT3L,WDR4,UBE2G2,CFAP410,ABCG1
- Function elements
- Human SNPs: Blond_vs._brown/black_hair_color
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 47
- Related genes and loops
- Related gene:
ENSG00000183486,
ENSG00000177398,
ENSG00000160179,
ENSG00000160191,
ENSG00000160193,
ENSG00000160194,
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160208,
ENSG00000160209,
ENSG00000160213,
ENSG00000160214,
ENSG00000160216,
ENSG00000160218,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000160233,
ENSG00000184787,
ENSG00000184900,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:41000000-41025000~~chr21:43350000-43375000,
chr21:41350000-41375000~~chr21:43350000-43375000,
chr21:41650000-41675000~~chr21:43350000-43375000,
chr21:41700000-41725000~~chr21:43350000-43375000,
chr21:42050000-42075000~~chr21:43350000-43375000,
chr21:42225000-42250000~~chr21:43350000-43375000,
chr21:42675000-42700000~~chr21:43350000-43375000,
chr21:42850000-42875000~~chr21:43350000-43375000,
chr21:42875000-42900000~~chr21:43350000-43375000,
chr21:42900000-42925000~~chr21:43350000-43375000,
chr21:42925000-42950000~~chr21:43350000-43375000,
chr21:42975000-43000000~~chr21:43350000-43375000,
chr21:43000000-43025000~~chr21:43350000-43375000,
chr21:43025000-43050000~~chr21:43350000-43375000,
chr21:43175000-43200000~~chr21:43350000-43375000,
chr21:43200000-43225000~~chr21:43350000-43375000,
chr21:43350000-43375000~~chr21:43475000-43500000,
chr21:43350000-43375000~~chr21:43575000-43600000,
chr21:43350000-43375000~~chr21:43600000-43625000,
chr21:43350000-43375000~~chr21:43625000-43650000,
chr21:43350000-43375000~~chr21:43650000-43675000,
chr21:43350000-43375000~~chr21:43700000-43725000,
chr21:43350000-43375000~~chr21:43725000-43750000,
chr21:43350000-43375000~~chr21:43750000-43775000,
chr21:43350000-43375000~~chr21:43775000-43800000,
chr21:43350000-43375000~~chr21:43875000-43900000,
chr21:43350000-43375000~~chr21:43900000-43925000,
chr21:43350000-43375000~~chr21:43925000-43950000,
chr21:43350000-43375000~~chr21:43950000-43975000,
chr21:43350000-43375000~~chr21:43975000-44000000,
chr21:43350000-43375000~~chr21:44000000-44025000,
chr21:43350000-43375000~~chr21:44025000-44050000,
chr21:43350000-43375000~~chr21:44050000-44075000,
chr21:43350000-43375000~~chr21:44250000-44275000,
chr21:43350000-43375000~~chr21:44275000-44300000,
chr21:43350000-43375000~~chr21:44300000-44325000,
chr21:43350000-43375000~~chr21:44325000-44350000,
chr21:43350000-43375000~~chr21:44375000-44400000,
chr21:43350000-43375000~~chr21:44425000-44450000,
chr21:43350000-43375000~~chr21:44450000-44475000,
chr21:43350000-43375000~~chr21:44725000-44750000,
chr21:43350000-43375000~~chr21:44775000-44800000,
chr21:43350000-43375000~~chr21:44800000-44825000,
chr21:43350000-43375000~~chr21:44925000-44950000,
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:43350000-43375000~~chr21:45325000-45350000,
chr21:43350000-43375000~~chr21:45350000-45375000,
chr21:43350000-43375000~~chr21:45450000-45475000,
chr21:6100000-6125000~~chr21:43350000-43375000,
chr21:6125000-6150000~~chr21:43350000-43375000,
chr21:6150000-6175000~~chr21:43350000-43375000,
chr21:6150000-6175000~~chr21:43375000-43400000,
chr21:6550000-6575000~~chr21:43350000-43375000,