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Basic information

CohesinDB ID: CDBP00420722

Locus: chr21-43576516-43576782

Data sourse: GSE138405, GSE98367

Cell type: Hela-Kyoto, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC3,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 69%, "5_TxWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, FOSL1, PGR, ZSCAN5C, SOX2, XBP1, FOXA1, HLF, SUZ12, ZFHX2, TFAP4, ATF3, THAP1, CHD7, ZNF532, CBFB, MECOM, SMARCE1, TP63, MITF, MYOG, JMJD1C, TEAD1, TRIM28, ETV1, LMO2, ESR1, OCA2, MLL, CTCF, TCF12, JUN, EP300, NUTM1, MNT, GATA6, PAX8, DPF2, E2F6, RFX5, ZNF528, TEAD4, KMT2B, TFAP2C, EED, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, POU5F1, TOP2A, RUNX1T1, ID3, CTBP1, ZNF317, ZNF263, ZBTB48, DUX4, STAT1, SRF, ERG2, TBP, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, EZH1, SMARCA4, ONECUT1, RAD21, GRHL3, GABPA, PRDM14, IKZF1, ZNF398, VDR, NR3C1, CEBPB, ZNF750, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, TRPS1, SPI1, IRF1, HDAC2, INTS13, GATA2, SIX2, FLI1, MXI1, NFIL3, NCOA2, RUNX1, SMC1A, CEBPA, SIRT6, EZH2phosphoT487, SIN3A, ZFX, TET2, ERG3, RARA, ZNF384, CREBBP, ZXDC, RUNX2, CDK6, GATA4, GR, ARNT, NRF1, ATF2, PBX3, FOXM1, CBFA2T3, CDK8, MED1, TEAD3, TERF1, MYB, PIAS1, ZNF3, NCOA1, EVI1, SREBF2, USF1, BCL11A, NIPBL, HNF4A, NR4A1, REST, CTBP2, TCF3, SMC3, STAG1, ZNF394, CBFA2T2, PPARG, AGO1, FOXA2, WT1, ESR2, FOXF1, MEF2C, HOXB13, KDM1A, YY1, RELA, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, PLAG1, KLF4, NCOA3, NR2F2, NR2F1, TP53, ZNF334, MYOD1, EGR2, T, AR, ZBTB16, RXR, ZBTB26, HSF1, NCOR1, BRD4, RNF2, JUND, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TSPEAR,PFKL,SLC37A1,C2CD2,CFAP410,PDXK,HSF2BP,PDE9A,TRPM2,PKNOX1,UBASH3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000160185, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160207, ENSG00000160209, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420722