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Basic information

CohesinDB ID: CDBP00420726

Locus: chr21-43582859-43583337

Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: False

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 68%, "5_TxWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, HMG20A, SOX2, XBP1, FOXA1, HLF, RXRB, MLL4, KDM3A, TFAP4, TSC22D4, BMI1, THRB, NFIC, ZFP64, ATF3, CHD7, PRDM1, ZNF532, CBFB, MXD4, SMARCE1, PAX5, TP63, MITF, ZNF736, CDX2, JMJD1C, KLF5, TEAD1, ZNF121, ELF1, KLF6, ETV1, TRIM28, SNAPC1, RCOR2, ESR1, HNF1B, MLL, ZNF217, TP73, HDAC8, USF2, CTCF, JUN, TCF12, EP300, NUTM1, L3MBTL4, MNT, ZBTB20, SOX5, BAF155, DPF2, SOX4, DMAP1, E2F6, SIX5, RFX5, DEK, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, MLX, PDX1, CHD8, POU5F1, MYCN, SRC, BRD3, CTBP1, ZBTB17, ZBTB48, SRF, GATAD1, SAP130, ARID3A, TBP, HNF4G, HOXC5, ERG, PAX6, SMARCC2, ETS1, EZH1, MYC, SMARCA4, HOMEZ, RAD21, LHX2, RXRA, NKX2-1, PROX1, GABPA, STAT3, ZNF614, XRCC5, UBN1, NKX3-1, MIER3, RCOR1, NR2F6, ARNTL, VDR, NR3C1, CEBPB, KMT2A, CREB1, TBL1XR1, BPTF, GRHL2, ZNF652, EBF3, TRPS1, MRTFA, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, GATA2, ZNF644, ZNF777, FLI1, DRAP1, ZGPAT, SREBF1, HCFC1, MXI1, NFIL3, ZC3H11A, MRTFB, NCOA2, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, EZH2phosphoT487, CBX1, AFF4, ZFX, SOX13, SIN3A, POU4F2, SMAD3, SP5, ZNF513, TWIST1, SMARCC1, RARA, NFYC, CREBBP, ZNF384, RUNX2, SMAD2, GATA4, GR, ARNT, PBX4, NFIB, DAXX, ZNF48, ATF2, CBFA2T3, PBX3, FOXM1, CHD1, CDK8, HMGXB4, FOS, MED1, TEAD3, ZEB1, CEBPD, SCRT2, ZNF3, KLF9, USF1, SP1, NIPBL, BCL11A, HNF4A, MAFK, IKZF5, REST, ARID1A, ARID2, ATF7, ZHX1, ASH2L, CTBP2, PHIP, MBD2, FOXP1, SMC3, ELL2, STAG2, MLLT1, STAG1, SKI, CBFA2T2, PPARG, FOXA2, CBX3, CREM, CHD2, NFATC1, RBBP5, MIER2, ZSCAN16, GTF2B, MAFF, ZNF30, SNAI2, TCF7, ZNF580, BCL3, TCOF1, KDM1A, YY1, RELA, HOXB13, NEUROD1, JUNB, BRCA1, ZIC2, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, ZNF449, KLF4, ZNF592, CEBPG, NCOA3, NR2F2, SP7, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, NFKB1, MYOD1, ELF3, BRD2, KAT8, PHF5A, ARID4B, AR, NFKBIZ, TAF1, ZNF579, BHLHE40, YAP1, EGLN2, EGR1, ZBTB26, HSF1, RNF2, BRD4, JUND, SCRT1, CUX1, MAZ, SMAD4.1D12, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): PDE9A,C2CD2,PFKL,TSPEAR,PDXK,CFAP410,TRPM2,SLC37A1,PKNOX1,HSF2BP,UBASH3A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000160185, ENSG00000160190, ENSG00000160191, ENSG00000160199, ENSG00000160207, ENSG00000160209, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420726