- Basic information
- CohesinDB ID: CDBP00420728
- Locus: chr21-43584938-43588325
-
Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE126634, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE25021, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE152721, GSE120943, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, GSE206145, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR000ECS
-
Cell type: RH4, SLK, Liver, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, H1-hESC, Monocytes, SK-N-SH, RT-112, HeLa-Tet-On, HAP1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, HeLa, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 39% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.667
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
70% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, HMG20A, SOX2, XBP1, FOXA1, HLF, RXRB, MLL4, KDM3A, TFAP4, TSC22D4, BMI1, THRB, NFIC, ZFP64, ATF3, CHD7, PRDM1, ZNF532, CBFB, MXD4, SMARCE1, PAX5, TP63, MITF, ZNF736, CDX2, JMJD1C, KLF5, TEAD1, ZNF121, ELF1, KLF6, ETV1, TRIM28, SNAPC1, RCOR2, ESR1, HNF1B, MLL, ZNF217, TP73, HDAC8, USF2, CTCF, JUN, TCF12, EP300, NUTM1, L3MBTL4, MNT, ZBTB20, SOX5, BAF155, DPF2, SOX4, DMAP1, E2F6, SIX5, RFX5, DEK, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, MLX, PDX1, CHD8, POU5F1, MYCN, SRC, BRD3, CTBP1, ZBTB17, ZBTB48, SRF, GATAD1, SAP130, ARID3A, TBP, HNF4G, HOXC5, ERG, PAX6, SMARCC2, ETS1, EZH1, MYC, SMARCA4, HOMEZ, RAD21, LHX2, RXRA, NKX2-1, PROX1, GABPA, STAT3, ZNF614, XRCC5, UBN1, NKX3-1, MIER3, RCOR1, NR2F6, ARNTL, VDR, NR3C1, CEBPB, KMT2A, CREB1, TBL1XR1, BPTF, GRHL2, ZNF652, EBF3, TRPS1, MRTFA, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HDAC2, GATA2, ZNF644, ZNF777, FLI1, DRAP1, ZGPAT, SREBF1, HCFC1, MXI1, NFIL3, ZC3H11A, MRTFB, NCOA2, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, EZH2phosphoT487, CBX1, AFF4, ZFX, SOX13, SIN3A, POU4F2, SMAD3, SP5, ZNF513, TWIST1, SMARCC1, RARA, NFYC, CREBBP, ZNF384, RUNX2, SMAD2, GATA4, GR, ARNT, PBX4, NFIB, DAXX, ZNF48, ATF2, CBFA2T3, PBX3, FOXM1, CHD1, CDK8, HMGXB4, FOS, MED1, TEAD3, ZEB1, CEBPD, SCRT2, ZNF3, KLF9, USF1, SP1, NIPBL, BCL11A, HNF4A, MAFK, IKZF5, REST, ARID1A, ARID2, ATF7, ZHX1, ASH2L, CTBP2, PHIP, MBD2, FOXP1, SMC3, ELL2, STAG2, MLLT1, STAG1, SKI, CBFA2T2, PPARG, FOXA2, CBX3, CREM, CHD2, NFATC1, RBBP5, MIER2, ZSCAN16, GTF2B, MAFF, ZNF30, SNAI2, TCF7, ZNF580, BCL3, TCOF1, KDM1A, YY1, RELA, HOXB13, NEUROD1, JUNB, BRCA1, ZIC2, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, ZNF143, ZNF449, KLF4, ZNF592, CEBPG, NCOA3, NR2F2, SP7, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, NFKB1, MYOD1, ELF3, BRD2, KAT8, PHF5A, ARID4B, AR, NFKBIZ, TAF1, ZNF579, BHLHE40, YAP1, EGLN2, EGR1, ZBTB26, HSF1, RNF2, BRD4, JUND, SCRT1, CUX1, MAZ, SMAD4.1D12, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PDXK,PKNOX1,C2CD2,PFKL,TSPEAR,TRPM2,CFAP410,UBASH3A,PDE9A,SLC37A1,HSF2BP
- Function elements
- Human SNPs: Diastolic_blood_pressure
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000157617,
ENSG00000160185,
ENSG00000160190,
ENSG00000160191,
ENSG00000160199,
ENSG00000160207,
ENSG00000160209,
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
- Related loop:
chr21:41625000-41650000~~chr21:43575000-43600000,
chr21:41925000-41950000~~chr21:43575000-43600000,
chr21:42425000-42450000~~chr21:43575000-43600000,
chr21:42525000-42550000~~chr21:43575000-43600000,
chr21:42575000-42600000~~chr21:43575000-43600000,
chr21:42725000-42750000~~chr21:43575000-43600000,
chr21:42800000-42825000~~chr21:43575000-43600000,
chr21:42925000-42950000~~chr21:43575000-43600000,
chr21:42975000-43000000~~chr21:43575000-43600000,
chr21:43000000-43025000~~chr21:43575000-43600000,
chr21:43175000-43200000~~chr21:43575000-43600000,
chr21:43200000-43225000~~chr21:43575000-43600000,
chr21:43250000-43275000~~chr21:43575000-43600000,
chr21:43300000-43325000~~chr21:43575000-43600000,
chr21:43325000-43350000~~chr21:43575000-43600000,
chr21:43350000-43375000~~chr21:43575000-43600000,
chr21:43575000-43600000~~chr21:43725000-43750000,
chr21:43575000-43600000~~chr21:44325000-44350000,
chr21:43575000-43600000~~chr21:44475000-44500000,
chr21:43575000-43600000~~chr21:44675000-44700000,
chr21:43584881-43587240~~chr21:43609260-43610484,
chr21:6025000-6050000~~chr21:43575000-43600000,
chr21:6125000-6150000~~chr21:43575000-43600000,
chr21:6425000-6450000~~chr21:43575000-43600000,