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Basic information

CohesinDB ID: CDBP00420732

Locus: chr21-43595004-43602071

Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE132649, ENCSR000BLY, ENCSR150EFU, GSE25021, GSE108869, ENCSR000EDW, ENCSR000BUC, GSE165895, ENCSR000EFJ, ENCSR000BTU, GSE67783, GSE138405, GSE76893, GSE101921, ShirahigeLab-NatGen2015, GSE138105, GSE130135, ENCSR199XBQ, GSE116344, ENCSR193NSH, ENCSR000BLS, ShirahigeLab, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR495WGO, ENCSR217ELF, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, ENCSR000ECS

Cell type: RH4, SLK, Liver, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, SK-N-SH, RT-112, T-47D, Hela-Kyoto, HEK293T, Hep-G2, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 22% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.767

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 36%, "7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, SOX2, MEIS2, XBP1, FOXA1, HLF, RXRB, PBX2, ZFHX2, KDM3A, TFAP4, HNRNPK, ATF3, THRB, NFIC, ZFP64, CHD7, PRDM1, ZNF532, ATF4, MXD4, SMARCE1, TP63, CDX2, TEAD1, ZNF121, RBM39, KLF6, ETV1, SNAI2, RCOR2, ESR1, OCA2, LMO2, USF2, CTCF, JUN, TCF12, EP300, NUTM1, KLF1, BAF155, SOX5, GATA6, TRIM24, RFX5, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, TFAP2C, MLX, RBPJ, GLIS1, CHD8, BRD1, ZNF263, HHEX, TOP2A, MYCN, BRD3, CTBP1, ZBTB17, ZBTB48, ZSCAN5A, DUX4, GATAD1, SAP130, ARID3A, ERG2, TBP, HNF4G, ERG, ETS1, MYC, SMARCA4, HOMEZ, RAD21, ARID1B, FOXP2, GRHL3, RXRA, NKX2-1, FOXK2, STAT3, XRCC5, ZNF614, NKX3-1, UBN1, IKZF1, MIER3, RCOR1, NR2F6, TERF2, VDR, HNRNPH1, NR3C1, CEBPB, ESRRA, HNRNPL, CREB1, TBL1XR1, EZH2, GRHL2, ZNF652, EBF3, ZHX2, SPI1, HES1, TFE3, MIXL1, IRF1, HDAC2, GATA2, ZNF182, ZNF644, SIX2, FLI1, DRAP1, ZGPAT, ZNF766, NFIL3, NCOA2, ZNF554, MRTFB, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, SIN3A, ZFX, SOX13, AFF4, POU4F2, SMAD3, ZNF335, ERG3, CBX8, SP5, TBX3, SMARCC1, TWIST1, MYBL2, RARA, ZNF384, CREBBP, PRPF4, NFYC, RUNX2, GATA4, ARNT, NRF1, PBX4, DAXX, ZNF48, ATF2, SMAD4, FOXM1, CBFA2T3, PBX3, SMARCB1, FOS, HMGXB4, MED1, TEAD3, ZNF3, C11orf30, SETDB1, SREBF2, MAFK, SP1, HNF4A, IKZF5, REST, ZHX1, ATF7, ASH2L, PHIP, FOXP1, PRDM6, AATF, SMC3, STAG2, SKI, CBFA2T2, PPARG, TBL1X, FOXA2, EBF1, CREM, CHD2, ZNF316, MIER2, ZNF600, GTF2B, MAFF, ESR2, TCF7, ZNF580, HOXB13, KDM1A, ZNF19, RELA, ZNF492, JUNB, AHR, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, GATA1, HAND2, CBX2, KLF4, CEBPG, NCOA3, NR2F2, ZNF281, ZNF512, TCF7L2, NEUROG2, NR2F1, KDM5B, TP53, PKNOX1, NFKB1, MYOD1, ELF3, PHF5A, KAT8, BRD2, NFKBIZ, ARID4B, AR, BHLHE40, TAF1, RXR, YAP1, ZNF324, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, BRD4, RNF2, JUND, MAZ, BRCA1, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): PDXK,PDE9A,UBASH3A,TRPM2,CFAP410,C2CD2,TSPEAR,PFKL,HSF2BP,SLC37A1,PKNOX1,NDUFV3

Function elements

Human SNPs: Mean_corpuscular_volume

Number of somatic mutations (coding): 36

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000157617, ENSG00000160185, ENSG00000160190, ENSG00000160191, ENSG00000160194, ENSG00000160199, ENSG00000160207, ENSG00000160209, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420732