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Basic information

CohesinDB ID: CDBP00420733

Locus: chr21-43602287-43614768

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 77% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.222

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 38%, "5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, ZNF675, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, ZNF322, IKZF3, TEAD1, ZNF121, OCA2, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ZNF157, SOX5, PYGO2, ZNF407, ZNF211, E2F4, ZNF410, NR5A2, ZNF528, GATAD2A, NANOG, BRD3, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ZNF488, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, UBN1, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, EPAS1, GABPB1, ZHX2, MIXL1, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, ZNF785, RELB, RUNX1, CEBPA, HDAC1, ZNF707, CRY1, NKX2-2, ZNF473, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZBTB10, ATF2, SNIP1, FOXM1, SMARCB1, TERF1, PML, ZNF331, SMAD1, PIAS1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, ARID2, IKZF5, MBD2, ELL2, CBFA2T2, ZNF207, CBX3, CREM, CHD2, SS18, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, MCM3, TCF4, ZFP36, ZNF311, BATF, SPIB, ZSCAN26, KLF4, ZFP69B, ZNF544, IRF5, ZBTB6, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, ZNF621, XBP1, PBX2, ZNF596, ATF3, ZC3H8, THRB, ZFP64, RUNX3, ZNF532, CBFB, ZNF273, TP63, ZSCAN4, MITF, CDC5L, ZNF467, MAF, MYOG, ELF1, RBM39, SNAI2, ZIK1, JUN, CTCF, L3MBTL4, LMO1, MNT, ZBTB20, DPF2, IRF4, ZNF423, ZNF776, ZNF280A, PLRG1, RBPJ, TFAP2C, MLX, YBX1, ZNF239, MTA2, ZSCAN21, ZBTB17, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, PHB2, CHD4, TRIP13, ZNF2, ZKSCAN2, FOXP2, HOMEZ, TSHZ1, RXRA, NKX3-1, LEF1, HNRNPH1, MIER3, VDR, NR3C1, ESRRA, FOXK1, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, ZNF292, EBF3, SSRP1, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, AFF4, SOX13, ZNF747, ZNF770, ZMIZ1, ZNF18, ZNF792, DAXX, ARNT, NFIB, ZNF48, HMBOX1, ZEB2, NFYA, PBX3, ETV6, ZNF10, HMGXB4, TEAD3, ZNF670, ZXDB, ZNF680, U2AF1, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, GLIS2, PRDM6, SMC3, STAG1, MLLT1, STAG2, MTA3, EBF1, MEIS1, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF266, ZNF155, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, ZNF141, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, SOX2, PATZ1, TFAP4, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, ZNF695, ZNF260, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZBTB1, ASH1L, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, ZNF114, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, ZNF652, MRTFA, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, NFYB, ZNF554, NCOA2, SALL2, ETV5, BCL6, SIN3A, NFXL1, ERG3, MYBL2, CREBBP, ZNF384, RARA, ZNF133, ZNF169, ZNF35, NFYC, ZNF280C, HMGB2, ZNF518A, SMAD4, CBFA2T3, CDK8, ZMYM3, NCOA1, ZNF22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HOXA9, HNRNPLL, BCOR, FOXP1, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF662, ZNF574, RELA, TARDBP, ZNF282, MAX, ZNF592, GFI1B, NEUROG2, ZNF791, KDM5B, TCF7L2, NR2F1, PKNOX1, MYOD1, T, AR, YAP1, ZNF324, AHR, FOSL2, DMAP1, HMG20A, LCORL, E2F7, ZSCAN5C, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF274, INSM2, NFIC, ZNF362, ZBTB5, PRDM1, MECOM, HDAC3, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, USF2, TCF12, EP300, NUTM1, BAF155, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, GATAD1, ARID3A, ZNF300, ZNF585B, ASCL1, MIER1, ZNF341, USP7, MCM5, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, FEZF1, TRPS1, HES1, ZNF664, EHF, TFE3, IRF1, HBP1, ZGPAT, MRTFB, MYF5, SMC1A, CBX1, MAFG, ZNF335, ZFX, SMAD3, PCBP2, CBX8, TWIST1, IRF2, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, SUPT5H, CHD1, MED1, CEBPD, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, HIF2A, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, SALL1, TCF3, SKI, NCOA4, KLF13, FOXA2, ZNF600, MIER2, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF521, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF354C, ZNF687, ZNF213, BHLHE40, NFKBIZ, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SLC37A1,NDUFV3,PKNOX1,HSF2BP

Function elements

Human SNPs: .

Number of somatic mutations (coding): 53

Number of somatic mutations (non-coding): 40

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160194, ENSG00000160199, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420733