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Basic information

CohesinDB ID: CDBP00420736

Locus: chr21-43619389-43620762

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE120943, GSE112028, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 52% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.344

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "9_Het": 40%, "15_Quies": 40%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, CHD8, SMC1A, FOXA2, CBX3, POU5F1, CRY1, ZFX, STAG2, XBP1, WT1, SMAD3, STAT1, FOXA1, SRF, CDK9, HOXB13, ERG, HOXC5, YY1, CREBBP, ZBTB2, AHR, RUNX2, EZH1, GATA4, ZNF280A, RAD21, PBX4, DAXX, TCF4, ARNT, SKIL, HIF1A, SMC3, GATA3, ZEB2, STAT3, TAL1, NRIP1, ZNF143, CDK8, IKZF1, MED1, CDX2, ZNF467, CEBPB, NCOA3, TEAD3, TRIM28, SCRT2, NR2F1, PIAS1, KDM5B, ESR1, KLF8, SETDB1, ZSCAN22, CTCF, TCF12, JUN, BAF155, NIPBL, EP300, HNF4A, AR, GATA6, SP1, SPI1, MIXL1, GATA2, REST, EGLN2, TRIM24, ZNF280D, BRD4, MAZ, ZNF528, SMC1, NCOA2, FOXA3, NCOR2, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): SLC37A1,NDUFV3,HSF2BP,PKNOX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160194, ENSG00000160199, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420736