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Basic information

CohesinDB ID: CDBP00420738

Locus: chr21-43624303-43624805

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE105028, GSE131606, GSE108869, GSE25021, ENCSR000BTU, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE116344, ENCSR703TNG, ENCSR000EEG, GSE98367, ENCSR000BLS, ENCSR000EHW, ENCSR000ECE, ENCSR000EHX, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS

Cell type: RH4, GM19240, HuCC-T1, H9-hESC, Ishikawa, HeLa-S3, K-562, DKO, H1-hESC, GM12891, SK-N-SH, GM19239, Macrophage, GM19099, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, GM19238

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 80%, "14_ReprPCWk": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SOX2, NME2, XBP1, FOXA1, RXRB, HNRNPK, ZNF90, ZNF532, TP63, TEAD1, TRIM28, ESR1, OCA2, TP73, CTCF, NUTM1, GATA6, PAX8, E2F6, TFAP2C, EED, POU2F2, CHD8, MYCN, BRD3, TOP2A, DUX4, STAT1, ERG2, ERG, MYC, EZH1, ONECUT1, RAD21, LHX2, GRHL3, RXRA, GABPA, STAT3, XRCC5, NKX3-1, RCOR1, NR3C1, CEBPB, KMT2A, EZH2, SPI1, GATA2, ZNF644, SIX2, FLI1, ZNF490, RELB, NCOA2, RUNX1, CBX1, SMC1A, SIRT6, NKX2-2, SOX13, ZFX, SMAD3, ERG3, SMARCC1, ZNF384, GATA4, ARNT, PRDM9, ETV6, CDK8, MED1, TEAD3, CEBPD, SCRT2, C11orf30, MAFK, BCL11A, SP1, HNF4A, ZNF605, STAG1, FOXA2, EBF1, GTF2B, MAFF, WT1, BCL3, KDM1A, RELA, AHR, ZFP36, HIF1A, OTX2, GATA3, MAX, ZNF143, KLF4, NCOA3, NR2F2, TP53, ZNF334, BHLHE40, AR, ZBTB26, RNF2, BRD4, SCRT1, CLOCK, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): HSF2BP,SLC37A1,PKNOX1,NDUFV3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160190, ENSG00000160194, ENSG00000160199, ENSG00000160207,

eachgene

Deatailed information for cohesin site CDBP00420738