- Basic information
- CohesinDB ID: CDBP00420747
- Locus: chr21-43640994-43641471
-
Data sourse: GSE67783, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE116344
-
Cell type: RPE, Fibroblast, RH4, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
70% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 63%,
"5_TxWk": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, ZNF496, HMG20A, E2F7, SOX2, NME2, XBP1, FOXA1, HLF, SUZ12, RXRB, ZFHX2, KDM3A, HDGF, ATF3, NFIC, ZNF362, CHD7, PRDM1, ZNF444, ZNF532, ATF4, PAX5, TP63, ZSCAN4, MITF, SFPQ, JMJD1C, TEAD1, ELF1, KLF6, SNAI2, SMAD5, ESR1, OCA2, LMO2, RCOR2, MLL, USF2, CTCF, JUN, TCF12, EP300, NUTM1, BAF155, MNT, SOX5, GATA6, DPF2, PAX8, TRIM24, RFX5, ZNF512B, SMC1, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, EED, GLIS1, POU2F2, CHD8, POU5F1, MYCN, TOP2A, ZNF263, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF205, DDX5, SAP130, ERG2, ARID3A, TBP, ZNF300, ERG, CHD4, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, NKX3-1, IKZF1, RCOR1, HNRNPH1, MIER3, ARNTL, NR3C1, ESRRA, SRSF3, CEBPB, HNRNPL, ZNF750, CREB1, EZH2, TBL1XR1, GRHL2, GABPB1, ZHX2, SPI1, MIXL1, EHF, HDAC2, SSRP1, GATA2, ZNF644, GATAD2B, MXD3, SIX2, FLI1, ZGPAT, MRTFB, NFIL3, RUNX1, THAP11, BCL6, SMC1A, CEBPA, SIN3A, ZFX, AFF4, SOX13, SMAD3, TET2, ERG3, CBX8, ZNF770, ZNF513, SMARCC1, PRDM10, CREBBP, ZNF384, RARA, TAF15, RUNX2, GATA4, ZNF184, PBX4, ARNT, NFIB, SOX11, PRDM9, SMAD4, FOS, CDK8, MED1, ZEB1, TEAD3, KDM6B, CEBPD, ZNF680, PIAS1, NR1H2, NCOA1, USF1, BCL11A, SP1, NIPBL, HNF4A, NKX2-5, REST, RBM25, POU2F3, ZHX1, ATF7, HNRNPLL, FOXP1, SMC3, ELL2, STAG2, STAG1, TRP47, ZNF316, AGO1, FOXA2, TBL1X, ZNF207, MTA3, PPARG, ZSCAN16, GTF2B, ZNF692, WT1, ESR2, ZNF662, ZBTB33, CDK9, HOXB13, KDM1A, ZNF19, RELA, YY1, TARDBP, JUNB, SP140, HIF1A, ZNF311, GATA3, MAX, ZNF143, GATA1, CBX2, CEBPG, KLF4, NCOA3, NR2F2, ZNF512, NEUROG2, TCF7L2, KDM5B, TP53, PKNOX1, NFKB1, EGR2, PHOX2B, ELF3, KAT8, BHLHE40, AR, RXR, ZNF324, EGLN2, EGR1, HSF1, RNF2, NCOR1, BRD4, JUND, SCRT1, CLOCK, CUX1, MAZ, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PKNOX1,HSF2BP,WDR4,SIK1,NDUFV3,SLC37A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 1
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160190,
ENSG00000160193,
ENSG00000160194,
ENSG00000160199,
ENSG00000142178,
ENSG00000160207,
- Related loop:
chr21:42150000-42175000~~chr21:43625000-43650000,
chr21:42575000-42600000~~chr21:43625000-43650000,
chr21:42600000-42625000~~chr21:43625000-43650000,
chr21:42800000-42825000~~chr21:43625000-43650000,
chr21:42806064-42807428~~chr21:43644880-43647795,
chr21:42850088-42851920~~chr21:43644933-43647734,
chr21:42850353-42851585~~chr21:43645063-43647595,
chr21:42875000-42900000~~chr21:43625000-43650000,
chr21:42900000-42925000~~chr21:43625000-43650000,
chr21:42922609-42925287~~chr21:43644896-43647868,
chr21:42922692-42925178~~chr21:43644727-43647870,
chr21:42922930-42925162~~chr21:43644933-43647734,
chr21:42922962-42925091~~chr21:43644228-43647626,
chr21:42922972-42925217~~chr21:43644939-43647696,
chr21:42923020-42925261~~chr21:43644178-43647643,
chr21:42925000-42950000~~chr21:43625000-43650000,
chr21:43000000-43025000~~chr21:43625000-43650000,
chr21:43175000-43200000~~chr21:43625000-43650000,
chr21:43200000-43225000~~chr21:43625000-43650000,
chr21:43209337-43212050~~chr21:43644682-43647799,
chr21:43209386-43212601~~chr21:43644722-43647651,
chr21:43210267-43212835~~chr21:43644178-43647643,
chr21:43210279-43212712~~chr21:43644144-43647779,
chr21:43275000-43300000~~chr21:43625000-43650000,
chr21:43300000-43325000~~chr21:43625000-43650000,
chr21:43325000-43350000~~chr21:43625000-43650000,
chr21:43342049-43344350~~chr21:43645041-43647656,
chr21:43350000-43375000~~chr21:43625000-43650000,
chr21:43425000-43450000~~chr21:43625000-43650000,
chr21:43475000-43500000~~chr21:43625000-43650000,
chr21:43610740-43612903~~chr21:43644956-43647859,
chr21:43611033-43612871~~chr21:43645066-43647744,
chr21:43611046-43612875~~chr21:43644727-43647870,
chr21:43611054-43612862~~chr21:43644979-43647872,
chr21:43611060-43612869~~chr21:43644944-43647839,
chr21:43611069-43612877~~chr21:43644732-43647818,
chr21:43611293-43612797~~chr21:43644991-43647619,
chr21:43611315-43614495~~chr21:43644986-43647633,
chr21:43613276-43614563~~chr21:43645000-43647610,
chr21:6075000-6100000~~chr21:43625000-43650000,
chr21:6100000-6125000~~chr21:43625000-43650000,
chr21:6125000-6150000~~chr21:43625000-43650000,
chr21:6425000-6450000~~chr21:43625000-43650000,
chr21:6500000-6525000~~chr21:43625000-43650000,
chr21:6550000-6575000~~chr21:43625000-43650000,