- Basic information
- CohesinDB ID: CDBP00420749
- Locus: chr21-43643270-43649915
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 87% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.089
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
70% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, POU2F2, CHD8, ZNF263, MYCN, ZFX, ZNF600, ZNF317, CTBP1, WT1, XBP1, ZSCAN5A, CBX8, YY1, RELA, ZNF384, MYC, RUNX2, SMARCA4, RAD21, SP140, GRHL3, HIF1A, ZNF532, ZFP36, OTX2, ETV6, FOS, GATA1, ZNF143, CBX2, NCOA3, SNAI2, EZH2, TP53, ESR1, OCA2, GRHL2, GABPB1, CTCF, NUTM1, RNF2, BRD4, CLOCK, MAZ, SMC3, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): SIK1,WDR4,SLC37A1,HSF2BP,PKNOX1,NDUFV3
- Function elements
- Human SNPs: Eosinophil_counts
- Number of somatic mutations (coding): 49
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160190,
ENSG00000160193,
ENSG00000160194,
ENSG00000160199,
ENSG00000142178,
ENSG00000160207,
- Related loop:
chr21:42125000-42150000~~chr21:43650000-43675000,
chr21:42150000-42175000~~chr21:43625000-43650000,
chr21:42575000-42600000~~chr21:43625000-43650000,
chr21:42600000-42625000~~chr21:43625000-43650000,
chr21:42600000-42625000~~chr21:43650000-43675000,
chr21:42800000-42825000~~chr21:43625000-43650000,
chr21:42806064-42807428~~chr21:43644880-43647795,
chr21:42850000-42875000~~chr21:43650000-43675000,
chr21:42850088-42851920~~chr21:43644933-43647734,
chr21:42850353-42851585~~chr21:43645063-43647595,
chr21:42875000-42900000~~chr21:43625000-43650000,
chr21:42875000-42900000~~chr21:43650000-43675000,
chr21:42900000-42925000~~chr21:43625000-43650000,
chr21:42900000-42925000~~chr21:43650000-43675000,
chr21:42922609-42925287~~chr21:43644896-43647868,
chr21:42922692-42925178~~chr21:43644727-43647870,
chr21:42922930-42925162~~chr21:43644933-43647734,
chr21:42922962-42925091~~chr21:43644228-43647626,
chr21:42922972-42925217~~chr21:43644939-43647696,
chr21:42923020-42925261~~chr21:43644178-43647643,
chr21:42925000-42950000~~chr21:43625000-43650000,
chr21:42925000-42950000~~chr21:43650000-43675000,
chr21:42975000-43000000~~chr21:43650000-43675000,
chr21:43000000-43025000~~chr21:43625000-43650000,
chr21:43000000-43025000~~chr21:43650000-43675000,
chr21:43025000-43050000~~chr21:43650000-43675000,
chr21:43175000-43200000~~chr21:43625000-43650000,
chr21:43175000-43200000~~chr21:43650000-43675000,
chr21:43200000-43225000~~chr21:43625000-43650000,
chr21:43200000-43225000~~chr21:43650000-43675000,
chr21:43209337-43212050~~chr21:43644682-43647799,
chr21:43209386-43212601~~chr21:43644722-43647651,
chr21:43210267-43212835~~chr21:43644178-43647643,
chr21:43210279-43212712~~chr21:43644144-43647779,
chr21:43275000-43300000~~chr21:43625000-43650000,
chr21:43300000-43325000~~chr21:43625000-43650000,
chr21:43300000-43325000~~chr21:43650000-43675000,
chr21:43325000-43350000~~chr21:43625000-43650000,
chr21:43325000-43350000~~chr21:43650000-43675000,
chr21:43342049-43344350~~chr21:43645041-43647656,
chr21:43350000-43375000~~chr21:43625000-43650000,
chr21:43350000-43375000~~chr21:43650000-43675000,
chr21:43425000-43450000~~chr21:43625000-43650000,
chr21:43475000-43500000~~chr21:43625000-43650000,
chr21:43610740-43612903~~chr21:43644956-43647859,
chr21:43611033-43612871~~chr21:43645066-43647744,
chr21:43611046-43612875~~chr21:43644727-43647870,
chr21:43611054-43612862~~chr21:43644979-43647872,
chr21:43611060-43612869~~chr21:43644944-43647839,
chr21:43611069-43612877~~chr21:43644732-43647818,
chr21:43611293-43612797~~chr21:43644991-43647619,
chr21:43611315-43614495~~chr21:43644986-43647633,
chr21:43613276-43614563~~chr21:43645000-43647610,
chr21:43650000-43675000~~chr21:43750000-43775000,
chr21:43650000-43675000~~chr21:44325000-44350000,
chr21:43650000-43675000~~chr21:44775000-44800000,
chr21:6075000-6100000~~chr21:43625000-43650000,
chr21:6100000-6125000~~chr21:43625000-43650000,
chr21:6100000-6125000~~chr21:43650000-43675000,
chr21:6125000-6150000~~chr21:43625000-43650000,
chr21:6425000-6450000~~chr21:43625000-43650000,
chr21:6500000-6525000~~chr21:43625000-43650000,
chr21:6550000-6575000~~chr21:43625000-43650000,
chr21:6550000-6575000~~chr21:43650000-43675000,