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Basic information

CohesinDB ID: CDBP00420751

Locus: chr21-43652784-43653261

Data sourse: GSE206145, GSE120943, GSE86191, GSE98367

Cell type: RPE, HCT-116, Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 75%, "5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, ZNF429, SRSF7, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, PYGO2, PAX8, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, RCOR1, NUFIP1, NR2F6, NFRKB, CD74, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, HCFC1, ZNF785, NR2C2, MXI1, DRAP1, RELB, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, ZNF707, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, GSPT2, IKZF5, ARID2, RBM25, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, PLAG1, ZFP69B, KLF4, BCL11B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, ATF3, THRB, ZFP64, RUNX3, WDHD1, ZNF532, CBFB, TP63, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, ZNF624, FUS, CTCF, JUN, TAF3, L3MBTL4, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF677, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, ONECUT1, ZNF2, HOMEZ, KDM4A, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, KDM5A, ZBTB14, ZNF146, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, LDB1, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, DAXX, NFIB, BACH1, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, MAFB, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, ZBTB18, TBX5, USF1, BCL11A, SP1, ATF7, ASH2L, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, KAT2B, ZNF266, BRG1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, SMAD4.1D12, PGR, FANCL, CBX5, SOX2, PATZ1, LEO1, RING1B, UBTF, TFAP4, SIN3B, BMI1, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ZMYND8, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, PHF21A, MCRS1, GABPA, STAT3, IKZF1, GFI1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF777, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, NFYC, ZNF35, TAF15, ZNF384, ZNF133, ZNF518A, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, ZNF791, NEUROG2, PKNOX1, RUVBL1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, ZNF395, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, ZNF90, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, ZNF506, THRAP3, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, NUTM1, EP300, GATA6, GLI4, CREB3, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, TFE3, HBP1, ZSCAN2, IRF1, SREBF1, GTF3C5, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, OSR2, ZNF184, CDK6, PBX4, NRF1, FOS, SUPT5H, CHD1, TGIF2, MED1, KDM6B, MYB, CEBPD, SCRT2, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF740, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): TRPM2,HSF2BP,UBE2G2,WDR4,PKNOX1,PDXK,UMODL1,CSTB,CFAP410,PFKL,NDUFV3,CBS

Function elements

Human SNPs: .

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160209, ENSG00000160213, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184787,

eachgene

Deatailed information for cohesin site CDBP00420751