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Basic information

CohesinDB ID: CDBP00420757

Locus: chr21-43667345-43668735

Data sourse: ENCSR167MTG, ENCSR338DUC, ENCSR230ZWH, GSE67783, GSE72082, GSE165895, GSE86191, ENCSR000HPG, ENCSR000BLS, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE138105, GSE25021, ENCSR917QNE

Cell type: Fibroblast, HCT-116, Hep-G2, SLK, IMR-90, K-562, Liver, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 70% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 71%, "4_Tx": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, ZSCAN5C, SOX2, FOXA1, RBFOX2, PBX2, RXRB, MLL4, ZFHX2, KDM3A, HDGF, ATF3, NFIC, RUNX3, ATF4, CBFB, GLYR1, PAX5, BACH2, JMJD1C, TEAD1, TRIM28, ZNF121, BCLAF1, RCOR2, ESR1, TP73, USF2, CTCF, JUN, TCF12, EP300, KLF1, ZNF695, SOX5, IRF4, ZNF528, FOXA3, ZNF175, GATAD2A, EED, GLIS1, POU2F2, MYCN, MTA2, DUX4, ZSCAN5A, STAT1, ZBTB48, SAP130, ERG2, ARID3A, HNF4G, HOXC5, PBX1, ETS1, MYC, ONECUT1, RAD21, GRHL3, RXRA, PROX1, NKX2-1, BATF3, STAT3, ZNF614, IKZF1, MIER3, DNMT3B, NR2F6, VDR, NR3C1, CEBPB, KMT2A, CREB1, GRHL2, ZHX2, SPI1, MIXL1, HDAC2, FLI1, ZGPAT, NFIL3, ZNF554, RUNX1, SMC1A, MAFG, CEBPA, SOX13, ZFX, SMAD3, ERG3, TBX3, SP5, MYBL2, RARA, ZNF384, ZNF35, RUNX2, DAXX, NRF1, ATF2, ZNF518A, SMAD4, PBX3, FOXM1, SUPT5H, ZNF484, CDK8, FOS, MED1, TEAD3, CEBPD, ZNF680, ZMYM3, ZNF3, C11orf30, TBX5, SREBF2, SETDB1, STAT5A, RBM22, MAFK, SP1, BCL11A, HNF4A, IKZF5, ATF7, ZNF543, TCF3, FOXP1, SMC3, MLLT1, STAG1, SKI, MEF2B, ZNF316, FOXA2, PPARG, EBF1, MEIS1, PAF1, NFATC1, ZNF600, ZNF692, GTF2B, WT1, MAFF, ESR2, MIER2, ZBTB33, MEF2C, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, AGO2, CEBPG, NCOA3, NR2F2, NR2F1, TP53, ZBTB6, MED, NFKB1, EGR2, PHF5A, ELF3, KAT8, TBX21, BHLHE40, AR, ARID4B, IKZF2, SCRT1, BRD4, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): PFKL,WDR4,PKNOX1,UMODL1,NDUFV3,RRP1B,PDXK,CBS,CSTB,UBE2G2,CFAP410,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 5

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000177398, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160200, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000184787,

eachgene

Deatailed information for cohesin site CDBP00420757