- Basic information
- CohesinDB ID: CDBP00420783
- Locus: chr21-43731350-43745389
-
Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE115250, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, GSE138105, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000EHX, ENCSR620NWG, ENCSR635OSG, ENCSR767DFK, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE83726, ENCSR000ECS
-
Cell type: MDM, RH4, SLK, Liver, TC-32, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, DKO, HFFc6, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, Macrophage, MCF-7, HCT-116, Hep-G2, A-549, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
70% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 32%,
"4_Tx": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: ZMYND11, ERG3
- Target gene symbol (double-evidenced CRMs): CBS,PKNOX1,HSF2BP,PDXK
- Function elements
- Human SNPs: Breast_cancer
- Number of somatic mutations (coding): 668
- Number of somatic mutations (non-coding): 177
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160200,
ENSG00000160207,
ENSG00000160209,
- Related loop:
chr21:41750000-41775000~~chr21:43750000-43775000,
chr21:42950000-42975000~~chr21:43750000-43775000,
chr21:43025000-43050000~~chr21:43725000-43750000,
chr21:43175000-43200000~~chr21:43725000-43750000,
chr21:43175000-43200000~~chr21:43750000-43775000,
chr21:43200000-43225000~~chr21:43750000-43775000,
chr21:43300000-43325000~~chr21:43750000-43775000,
chr21:43350000-43375000~~chr21:43725000-43750000,
chr21:43350000-43375000~~chr21:43750000-43775000,
chr21:43575000-43600000~~chr21:43725000-43750000,
chr21:43650000-43675000~~chr21:43750000-43775000,
chr21:43727794-43729810~~chr21:43775194-43777378,
chr21:43727966-43729871~~chr21:43788671-43790700,
chr21:43750000-43775000~~chr21:43850000-43875000,
chr21:43750000-43775000~~chr21:43875000-43900000,
chr21:43750000-43775000~~chr21:44000000-44025000,
chr21:43750000-43775000~~chr21:44250000-44275000,
chr21:43750000-43775000~~chr21:44325000-44350000,
chr21:43750000-43775000~~chr21:44475000-44500000,
chr21:6550000-6575000~~chr21:43725000-43750000,