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Basic information

CohesinDB ID: CDBP00420784

Locus: chr21-43745728-43760952

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE93080, ENCSR000EAC, GSE143937, GSE67783, ENCSR000BKV, GSE122299, GSE138405, GSE86191, GSE206145-NatGen2015, GSE120943, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000EHX, ENCSR000BTQ, GSE38395, ENCSR167MTG, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893

Cell type: RH4, GM10847, GM19240, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HeLa-S3, hLCL, IMR-90, K-562, GM18486, DKO, H1-hESC, SNYDER, Monocytes, MB157, GM12878, GM12891, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, HUVEC, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 20% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.611

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 73% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 42%, "5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NME2, XBP1, PATZ1, FOXA1, RBFOX2, PBX2, LEO1, ZNF28, ZFHX2, HDGF, ATF3, THAP1, ZNF189, TP63, ELF1, ZNF121, RBM39, SNAI2, SMAD5, ESR1, TP73, HDAC8, USF2, JUN, CTCF, TCF12, KLF1, DPF2, TRIM24, IRF4, SOX6, DDX20, ZNF528, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, CHD8, ZSCAN5D, POU5F1, MYCN, ZNF263, ID3, RUNX1T1, ZMYND11, MTA2, ZBTB48, ZSCAN5A, STAT1, ZNF485, NBN, SP4, ERG, OGG1, MYC, SMARCA4, ARID1B, GRHL3, KLF12, FOXK2, GABPA, STAT3, ZNF614, NFE2, HNRNPH1, DNMT3B, DACH1, RCOR1, ZNF639, NR3C1, CEBPB, SRSF3, CREB1, KLF8, ZHX2, SPI1, KLF17, PCBP1, HDAC2, GATA2, MXD3, ZNF146, FLI1, SMARCA5, ATF1, ETV5, RUNX1, MAFG, HDAC1, SIRT6, LDB1, CRY1, ZFX, PCBP2, TET2, ERG3, ZNF770, NSD2, ZNF384, CDK6, OSR2, ARNT, NRF1, SOX11, ZNF48, PRDM9, ZEB2, PBX3, CBFA2T3, SUPT5H, CHD1, TEAD3, PML, CEBPD, SUPT16H, ZNF3, C11orf30, SETDB1, STAT5A, RBM22, BCL11A, SP1, REST, ZBTB7A, RBM25, HNRNPLL, TCF3, MBD2, BCOR, AATF, STAG1, MLLT1, TRP47, CBFA2T2, ZNF316, FOXA2, RBBP5, PAF1, NFATC1, WT1, ZBTB33, BCL3, ZKSCAN1, RELA, NEUROD1, SP140, ZFP36, MAF1, MAX, TAL1, GATA1, AGO2, ZNF143, PLAG1, KLF4, NCOA3, NR2F2, ZNF83, NR2F1, KDM5B, TP53, PKNOX1, NFKB1, EGR2, ZNF140, AR, EGLN2, HSF1, ZBTB26, RNF2, BRD4, ILF3, NCOR1, JUND, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): CFAP410,RIPK4,RRP1B,CBS,TRAPPC10,PKNOX1,HSF2BP,TRPM2,PDXK,AGPAT3,PFKL,DNMT3L,TSPEAR

Function elements

Human SNPs: .

Number of somatic mutations (coding): 699

Number of somatic mutations (non-coding): 233

Related genes and loops

Related gene: ENSG00000183421, ENSG00000160199, ENSG00000160200, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420784