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Basic information

CohesinDB ID: CDBP00420785

Locus: chr21-43761154-43780032

Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR895JMI, GSE118494, ENCSR338DUC, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE64758, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE111537, GSE25021, GSE76893, ENCSR217ELF, GSE131956, GSE110061, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR981FDC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 51% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.300

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 29%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOXA1, MLL4, HDGF, ZBTB44, IKZF3, MORC2, ZNF121, LMO2, OCA2, HDAC8, ZNF561, E4F1, PYGO2, PAX8, DEK, E2F4, ZNF528, NANOG, ZNF263, POU5F1, BRD3, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, FOXK2, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, FLI1, HCFC1, NR2C2, MXI1, ZNF785, HCFC1R1, EP400, RUNX1, HDAC1, NKX2-2, CEBPA, CRY1, TET2, SP5, SMARCC1, PRDM10, ZXDC, ZBTB2, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, SMAD1, NR1H2, C11orf30, STAT5A, GSPT2, ARID2, IKZF5, MBD2, ELL2, CBFA2T2, CBX3, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, NEUROD1, JUNB, ZFP36, PLAG1, KLF4, BCL11B, ZNF281, ZBTB6, EGR2, ELF3, RXR, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, PBX2, ATF3, ZFP64, RUNX3, TP63, ZSCAN4, MITF, CDC5L, ZNF467, MAF, ELF1, RBM39, KLF10, ZNF624, ZNF571, CTCF, JUN, ZBTB20, MNT, DPF2, RYBP, SIX5, ZNF423, RBPJ, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, DDX5, NBN, CHD4, ZNF2, HOMEZ, FOXP2, RXRA, PRDM14, LEF1, HNRNPH1, NR3C1, ESRRA, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, SSRP1, ZSCAN29, SMARCA5, CC2D1A, AFF4, SOX13, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ETV6, ZNF10, HMGXB4, TEAD3, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KAT2B, ZIC2, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, NFKB1, ZNF140, PHOX2B, BRD2, EGR1, RB1, RNF2, JUND, BRD4, ZSCAN23, IRF9, PGR, SOX2, PATZ1, LEO1, UBTF, TFAP4, CHD7, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ZMYND8, ERG2, SP4, HIC1, TBP, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, PHF21A, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, NFE2L1, PHF8, SPI1, PCBP1, HDAC2, NFYB, ZNF76, ZNF554, ETV5, GTF2A2, BCL6, SIN3A, ZFP37, ERG3, RARA, ZNF384, CREBBP, TAF15, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, AATF, ZNF34, PPARG, TBL1X, ZNF692, GTF2B, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, ZNF547, MYOD1, AR, ZNF324, HEXIM1, ZNF280D, ZNF395, AHR, FOSL2, DMAP1, ZNF391, E2F7, ZSCAN5C, HMGN3, RBFOX2, ZFHX2, INSM2, NFIC, CTCFL, PRDM1, CDX2, ZNF629, KLF5, TRIM28, ETV1, USF2, TCF12, EP300, GATA6, GLI4, CREB3, SOX6, ZNF512B, E2F1, TEAD4, ZNF175, CHD8, BRD1, MYCN, ID3, HINFP, GATAD1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, NFE2, ZNF639, ARNTL, ZNF750, IRF1, SREBF1, MRTFB, ATF1, PTBP1, CBX1, SMC1A, MAFG, SIRT6, ZFX, ZNF534, SMAD3, TWIST1, NSD2, IRF2, PRPF4, BRD9, RUNX2, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, SUPT5H, FOS, CHD1, MED1, KDM6B, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, SP140, HIF1A, OTX2, ZNF449, GATA1, SP7, NCOA3, NR2F2, ZNF83, ZNF687, BHLHE40, NFKBIZ, PTRF, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, MEF2D, BRCA1

Target gene symbol (double-evidenced CRMs): CSTB,DNMT3L,NDUFV3,AGPAT3,PFKL,RRP1B,WDR4,TSPEAR,PKNOX1,HSF2BP,CFAP410,RIPK4,TRAPPC10,TRPM2,PDXK,RRP1

Function elements

Human SNPs: Systolic_blood_pressure_change_trajectory

Number of somatic mutations (coding): 182

Number of somatic mutations (non-coding): 72

Related genes and loops

Related gene: ENSG00000183421, ENSG00000160193, ENSG00000160194, ENSG00000160199, ENSG00000160207, ENSG00000160208, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420785