Deatailed information for cohesin site CDBP00420786

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  • Basic information
  • CohesinDB ID: CDBP00420786
  • Locus: chr21-43780561-43783971
  • Data sourse: ENCSR230ZWH, GSE72082, GSE116868, GSE111537, GSE25021, GSE131606, ENCSR000EDW, ENCSR917QNE, GSE67783, GSE86191, GSE76893, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE85526, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, ENCSR000ECS
  • Cell type: MCF-7, Macrophage, HCT-116, Hep-G2, HEKn, MB157, HeLa-S3, RT-112, K-562, Liver, OCI-AML-3, HSPC, HuCC-T1, DKO
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 8% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 33%, "5_TxWk": 31%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, SOX2, XBP1, HNF1A, PATZ1, FOXA1, HLF, SUZ12, RBFOX2, RXRB, MLL4, KDM3A, TFAP4, HDGF, TSC22D4, THRB, ATF3, ZFP64, RUNX3, CBFB, MXD4, SMARCE1, PAX5, TP63, CDX2, JMJD1C, KLF5, TEAD1, BCLAF1, ELF1, KLF6, SNAI2, RCOR2, ZNF217, ESR1, MLL, OCA2, HDAC8, CTCF, TCF12, JUN, EP300, KLF1, E4F1, MNT, L3MBTL4, SOX5, GATA6, DPF2, DMAP1, IRF4, RFX5, RAD51, U2AF2, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, PDX1, MLX, RBPJ, EED, TFAP2C, POU2F2, MYCN, BRD3, ZNF263, CTBP1, MTA2, ZNF317, ZBTB48, STAT1, SRF, GATAD1, SAP130, NBN, ARID3A, TBP, HNF4G, ERG, ASCL1, ETS1, MYC, HOMEZ, ARID1B, RAD21, GRHL3, PROX1, RXRA, GABPA, MCRS1, STAT3, XRCC5, ZNF614, APC, IKZF1, MIER3, RCOR1, NR2F6, HNRNPH1, DNMT3B, TCF25, ZNF750, CEBPB, NR3C1, ESRRA, SRSF3, KMT2A, CREB1, CCAR2, EZH2, TBL1XR1, GRHL2, ZNF652, GABPB1, ZHX2, SPI1, MIXL1, TFE3, EHF, IRF1, HDAC2, GATA2, SSRP1, ZNF644, MXD3, DRAP1, ZGPAT, SMARCA5, RELB, NFIL3, ZIM3, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, CBX1, SOX13, ZFX, POU4F2, AFF4, SIN3A, SMAD3, TET2, SP5, TRIM22, SMARCC1, RARA, CREBBP, NOTCH1, NFYC, GATA4, OSR2, ARNT, PBX4, SOX11, ZNF48, ATF2, SMAD4, ZEB2, PBX3, ZNF10, SMARCB1, CDK8, FOS, HMGXB4, TGIF2, MED1, TEAD3, ZEB1, CEBPD, MYB, SCRT2, ZMYM3, PIAS1, U2AF1, ZNF3, NR1H2, NCOA1, MBD1, MAFK, BCL11A, SP1, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, RBM25, ATF7, ASH2L, HNRNPLL, TCF3, FOXP1, BCOR, PRDM6, SMC3, ELL2, NCOR2, MLLT1, STAG1, ETV4, NFATC3, SKI, MEF2B, PPARG, FOXA2, AGO1, EBF1, ZNF316, CREM, E2F8, ZNF600, MIER2, ZNF692, WT1, MAFF, ZBTB33, TCF7, MEF2C, CDK9, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, MCM3, SP140, TCF4, ZFP36, SKIL, HIF1A, BHLHE22, ZNF311, GATA3, BATF, TAL1, MAX, ZNF143, GATA1, CEBPG, KLF4, NR2F2, NR2F1, TCF7L2, ZNF687, TP53, NFKB1, MYOD1, ELF3, PHF5A, KAT8, BRD2, TBX21, ARID4B, BHLHE40, AR, NFKBIZ, TAF1, EGLN2, ZNF366, EGR1, RB1, ZBTB26, HSF1, BRD4, JUND, CUX1, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): TRAPPC10,WDR4,NDUFV3,CSTB,PFKL
  • Function elements
  • Human SNPs: Blood_protein_levels_in_cardiovascular_risk
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 14
  • Related genes and loops
  • Related gene: ENSG00000160193, ENSG00000160194, ENSG00000160213, ENSG00000160218, ENSG00000141959,
  • Related loop: chr21:42875000-42900000~~chr21:43775000-43800000, chr21:43350000-43375000~~chr21:43775000-43800000, chr21:43717830-43720923~~chr21:43788650-43790245, chr21:43718134-43720810~~chr21:43788562-43790300, chr21:43727794-43729810~~chr21:43775194-43777378, chr21:43727966-43729871~~chr21:43788671-43790700, chr21:43775000-43800000~~chr21:44000000-44025000, chr21:43775000-43800000~~chr21:44275000-44300000, chr21:43775010-43777246~~chr21:43788671-43790700, chr21:43775246-43777294~~chr21:43788686-43790650, chr21:43788328-43790829~~chr21:43804831-43806258, chr21:43788506-43790376~~chr21:43804838-43806274,
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