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Basic information

CohesinDB ID: CDBP00420791

Locus: chr21-43796477-43821123

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 82% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.100

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 24%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, ZNF322, IKZF3, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ARID5B, E4F1, SOX5, PAX8, E2F4, DEK, ZNF410, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, POU5F1, ZNF263, TOP2A, CTBP1, ERF, ZMYND11, DUX4, STAT1, SAP130, ZNF485, ERG, ZBTB21, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF8, UBN1, RCOR1, NR2F6, CD74, DACH1, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, NR2C2, ZNF785, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZXDC, ELK1, ZBTB10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, ZNF605, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF221, PBX2, HNRNPK, THRB, ATF3, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, TP63, MITF, BACH2, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, MNT, LMO1, ZBTB20, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF280A, PDX1, RBPJ, MLX, TFAP2C, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PBX1, ZNF2, HOMEZ, KDM4A, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, ZBTB24, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, NFIB, ARNT, BACH1, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAT2, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, ZNF468, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, SND1, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ZNF224, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF76, NFYB, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF384, NFYC, ZNF35, TAF15, CREBBP, ZNF169, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, TCF7, FOXO3, ZFP14, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, KMT2D, AR, ZNF445, ZBTB16, YAP1, ZNF324, HEXIM1, ZNF280D, AHR, DMAP1, FOSL2, MBD3, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF529, INSM2, NFIC, CTCFL, KLF14, MECOM, ZNF736, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, GMEB2, ARID3A, USP7, ASCL1, ZNF341, MIER1, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ARNTL, ZNF750, JMJD6, FEZF1, TFE3, HBP1, EHF, IRF1, GTF3C5, SREBF1, ZGPAT, NAB2, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, SMC1A, MAFG, SIRT6, ZNF335, FIP1L1, ZFX, SMAD3, NMYC, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, SMAD2, ZNF184, ZSCAN30, OSR2, NRF1, GR, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): LRRC3,TRPM2,RRP1,AGPAT3,CFAP410,TRAPPC10,WDR4,TSPEAR,PFKL,NDUFV3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 218

Number of somatic mutations (non-coding): 310

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160194, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420791