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Basic information

CohesinDB ID: CDBP00420792

Locus: chr21-43821535-43822584

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 74%, "14_ReprPCWk": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, ZNF322, IKZF3, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ARID5B, E4F1, SOX5, PAX8, E2F4, DEK, ZNF410, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, POU5F1, ZNF263, TOP2A, CTBP1, ERF, ZMYND11, DUX4, STAT1, SAP130, ZNF485, ERG, ZBTB21, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, TOP1, FOXK2, ZNF8, UBN1, RCOR1, NR2F6, CD74, DACH1, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, NR2C2, ZNF785, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZXDC, ELK1, ZBTB10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, ZNF605, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF221, PBX2, HNRNPK, THRB, ATF3, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, TP63, MITF, BACH2, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, CTCF, TAF3, MNT, LMO1, ZBTB20, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF280A, PDX1, RBPJ, MLX, TFAP2C, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, PBX1, ZNF2, HOMEZ, KDM4A, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, ZBTB24, LDB1, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, SP3, NFIB, ARNT, BACH1, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAT2, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, ZNF468, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, SND1, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ELK4, ZNF224, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, ZNF76, NFYB, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF384, NFYC, ZNF35, TAF15, CREBBP, ZNF169, SMAD4, CBFA2T3, CDK8, SNRNP70, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, TCF7, FOXO3, ZFP14, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, KMT2D, AR, ZNF445, ZBTB16, YAP1, ZNF324, HEXIM1, ZNF280D, AHR, DMAP1, FOSL2, MBD3, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF529, INSM2, NFIC, CTCFL, KLF14, MECOM, ZNF736, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, GMEB2, ARID3A, USP7, ASCL1, ZNF341, MIER1, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, TCF25, ZNF639, ARNTL, ZNF750, JMJD6, FEZF1, TFE3, HBP1, EHF, IRF1, GTF3C5, SREBF1, ZGPAT, NAB2, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, SMC1A, MAFG, SIRT6, ZNF335, FIP1L1, ZFX, SMAD3, NMYC, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, SMAD2, ZNF184, ZSCAN30, OSR2, NRF1, GR, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, CEBPD, KDM6B, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): AGPAT3,LRRC3,TSPEAR,CFAP410,PFKL,TRPM2,TRAPPC10

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000160216, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420792