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Basic information

CohesinDB ID: CDBP00420793

Locus: chr21-43823281-43831732

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE165895, GSE138405, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, GSE112028, GSE93080, ENCSR703TNG, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, GSE168045, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, GSE38411, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, RH4, GM2610, GM19240, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, SC, A-549, HUVEC, GM19238, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 38% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.456

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "14_ReprPCWk": 24%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, UBTF, PBX2, TFAP4, HDGF, LYL1, ATF3, NFIC, ZFP64, CTCFL, RUNX3, CBFB, MECOM, TP63, MITF, ZNF736, JMJD1C, TEAD1, TRIM28, ZNF121, ELF1, ETV1, NFE2L2, LMO2, ESR1, OCA2, MLL, HDAC8, USF2, CTCF, TCF12, JUN, EP300, KLF1, SOX5, GATA6, DPF2, E2F6, TRIM24, SOX6, E2F4, RAD51, ZNF280A, TEAD4, GATAD2A, GTF2F1, TFAP2C, RBPJ, GLIS1, POU2F2, BRD1, MYCN, ZNF263, RUNX1T1, ID3, TOP2A, CTBP1, MTA2, ZNF317, ZBTB48, ZSCAN5A, STAT1, ZNF563, GATAD1, SAP130, SRF, ERG, OGG1, ZNF341, ETS1, EZH1, MYC, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, NKX2-1, APC, XRCC5, ZNF614, STAT3, NKX3-1, IKZF1, RCOR1, DNMT3B, ZNF667, NFE2, VDR, PRDM14, NR3C1, CEBPB, SRSF3, HNRNPH1, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, GABPB1, SPI1, MIXL1, KDM5A, ZNF257, HDAC2, GATA2, MXD3, FLI1, DRAP1, SMARCA5, ZIM3, ATF1, ETV5, PTBP1, RUNX1, SMC1A, BCL6, HDAC1, CEBPA, CBX1, SIN3A, ZFX, ZNF534, TET2, ZNF770, PRDM10, ZBTB2, ZNF384, CREBBP, TAF15, RUNX2, CDK6, ARNT, NFIB, ZNF48, ZEB2, SMAD4, HMBOX1, PBX3, CBFA2T3, SUPT5H, FOS, CHD1, CDK8, MED1, TEAD3, MYB, VEZF1, ZNF3, KLF9, L3MBTL2, SETDB1, EVI1, USF1, BCL11A, HNF4A, NR4A1, REST, ZNF479, ZBTB7A, ATF7, ZHX1, HNRNPLL, PCGF2, AFF1, TCF3, BCOR, AATF, SMC3, MLLT1, STAG1, NFATC3, ZNF394, TRP47, CBFA2T2, CBX3, MTA3, CREM, RBBP5, PAF1, AGO1, ZNF600, FOXA2, WT1, ZNF30, ZNF574, ZBTB33, CDK9, HOXB13, ZNF580, ZKSCAN1, CREB3L1, KDM1A, RELA, YY1, TARDBP, NEUROD1, BRG1, ZNF282, SP140, ZIC2, HIF1A, ZFP36, GATA3, MGA, TAL1, MAX, MAF1, ZNF449, ZNF143, GATA1, NRIP1, PLAG1, ZNF592, GFI1B, NR2F2, NCOA3, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, ZBTB6, ZNF334, ZNF140, ARID4B, AR, BHLHE40, TAF1, ZBTB16, ZBTB40, RXR, EGLN2, HEXIM1, RB1, EGR1, ZBTB26, NCOR1, RNF2, BRD4, JUND, ILF3, HSF1, MAZ, ZNF24, AHR

Target gene symbol (double-evidenced CRMs): CFAP410,DNMT3L,TRPM2,TSPEAR,PFKL,LRRC3,TRAPPC10,AGPAT3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 41

Related genes and loops

Related gene: ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160233, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420793