Deatailed information for cohesin site CDBP00420794

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  • Basic information
  • CohesinDB ID: CDBP00420794
  • Locus: chr21-43831999-43836730
  • Data sourse: ENCSR000BLD, ENCSR000BTU, GSE118494, GSE67783, GSE111537, GSE72082, GSE86191, GSE98367, GSE116868, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE120943, ENCSR153HNT, ENCSR703TNG, GSE25021, GSE50893
  • Cell type: MCF-7, GM12892, H1-hESC, Fibroblast, HCT-116, Macrophage, Hep-G2, MB157, Monocytes, RPE, Ishikawa, IMR-90, K-562, OCI-AML-3, HSPC, GM18486
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 5% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.822
  • Subunit: SA1,Rad21,SA2,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "14_ReprPCWk": 32%, "15_Quies": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, MEIS2, XBP1, FOXA1, SUZ12, RBFOX2, LEO1, UBTF, PBX2, TFAP4, HDGF, LYL1, ATF3, NFIC, ZFP64, CTCFL, RUNX3, CBFB, MECOM, TP63, MITF, ZNF736, JMJD1C, TEAD1, TRIM28, ZNF121, ELF1, ETV1, NFE2L2, LMO2, ESR1, OCA2, MLL, HDAC8, USF2, CTCF, TCF12, JUN, EP300, KLF1, SOX5, GATA6, DPF2, E2F6, TRIM24, SOX6, E2F4, RAD51, ZNF280A, TEAD4, GATAD2A, GTF2F1, TFAP2C, RBPJ, GLIS1, POU2F2, BRD1, MYCN, ZNF263, RUNX1T1, ID3, TOP2A, CTBP1, MTA2, ZNF317, ZBTB48, ZSCAN5A, STAT1, ZNF563, GATAD1, SAP130, SRF, ERG, OGG1, ZNF341, ETS1, EZH1, MYC, SMARCA4, HOMEZ, RAD21, ARID1B, GRHL3, NKX2-1, APC, XRCC5, ZNF614, STAT3, NKX3-1, IKZF1, RCOR1, DNMT3B, ZNF667, NFE2, VDR, PRDM14, NR3C1, CEBPB, SRSF3, HNRNPH1, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, GABPB1, SPI1, MIXL1, KDM5A, ZNF257, HDAC2, GATA2, MXD3, FLI1, DRAP1, SMARCA5, ZIM3, ATF1, ETV5, PTBP1, RUNX1, SMC1A, BCL6, HDAC1, CEBPA, CBX1, SIN3A, ZFX, ZNF534, TET2, ZNF770, PRDM10, ZBTB2, ZNF384, CREBBP, TAF15, RUNX2, CDK6, ARNT, NFIB, ZNF48, ZEB2, SMAD4, HMBOX1, PBX3, CBFA2T3, SUPT5H, FOS, CHD1, CDK8, MED1, TEAD3, MYB, VEZF1, ZNF3, KLF9, L3MBTL2, SETDB1, EVI1, USF1, BCL11A, HNF4A, NR4A1, REST, ZNF479, ZBTB7A, ATF7, ZHX1, HNRNPLL, PCGF2, AFF1, TCF3, BCOR, AATF, SMC3, MLLT1, STAG1, NFATC3, ZNF394, TRP47, CBFA2T2, CBX3, MTA3, CREM, RBBP5, PAF1, AGO1, ZNF600, FOXA2, WT1, ZNF30, ZNF574, ZBTB33, CDK9, HOXB13, ZNF580, ZKSCAN1, CREB3L1, KDM1A, RELA, YY1, TARDBP, NEUROD1, BRG1, ZNF282, SP140, ZIC2, HIF1A, ZFP36, GATA3, MGA, TAL1, MAX, MAF1, ZNF449, ZNF143, GATA1, NRIP1, PLAG1, ZNF592, GFI1B, NR2F2, NCOA3, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, ZBTB6, ZNF334, ZNF140, ARID4B, AR, BHLHE40, TAF1, ZBTB16, ZBTB40, RXR, EGLN2, HEXIM1, RB1, EGR1, ZBTB26, NCOR1, RNF2, BRD4, JUND, ILF3, HSF1, MAZ, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): PFKL,TSPEAR,DNMT3L,CFAP410,AGPAT3,TRAPPC10
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 31
  • Related genes and loops
  • Related gene: ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000175894,
  • Related loop: chr21:43825000-43850000~~chr21:43925000-43950000, chr21:43825000-43850000~~chr21:43950000-43975000, chr21:43825000-43850000~~chr21:44075000-44100000, chr21:43825000-43850000~~chr21:44250000-44275000, chr21:43825000-43850000~~chr21:44275000-44300000, chr21:43825000-43850000~~chr21:44300000-44325000, chr21:43825000-43850000~~chr21:44475000-44500000, chr21:43826555-43827748~~chr21:43938146-43939967, chr21:5125000-5150000~~chr21:43825000-43850000,
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