- Basic information
- CohesinDB ID: CDBP00420798
- Locus: chr21-43844363-43846062
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Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE105028, GSE131606, GSE25021, ENCSR000EDW, ENCSR917QNE, ENCSR000EFJ, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE145327, GSE106870, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE129526, ENCSR054FKH, ENCSR153HNT
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, Hep-G2, CVB-hiPSC, DKO, HUES64, IMR-90, K-562, Liver, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
79% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 70%,
"14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, SMC1A, CHD8, BRD1, POU5F1, MYCN, ZFX, XBP1, SMAD3, ZBTB48, WT1, STAT1, NBN, HOXB13, ERG, YY1, RELA, ZBTB2, ZNF384, ATF3, EZH1, RAD21, SP140, ARNT, HIF1A, FOXP2, GRHL3, GABPA, PAX5, XRCC5, MAX, GATA1, ZNF143, ZNF467, PLAG1, NCOA3, SMAD1, ZNF3, ESR1, GRHL2, CTCF, TCF12, AR, DPF2, PTBP1, HNRNPLL, BRD4, BCOR, MAZ, SMC3, ZNF24, STAG1
- Target gene symbol (double-evidenced CRMs): TRAPPC10,DNMT3L,TSPEAR,AGPAT3,PFKL,CFAP410
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000160216,
ENSG00000160218,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
ENSG00000175894,
- Related loop:
chr21:43175000-43200000~~chr21:43850000-43875000,
chr21:43300000-43325000~~chr21:43850000-43875000,
chr21:43750000-43775000~~chr21:43850000-43875000,
chr21:43825000-43850000~~chr21:43925000-43950000,
chr21:43825000-43850000~~chr21:43950000-43975000,
chr21:43825000-43850000~~chr21:44075000-44100000,
chr21:43825000-43850000~~chr21:44250000-44275000,
chr21:43825000-43850000~~chr21:44275000-44300000,
chr21:43825000-43850000~~chr21:44300000-44325000,
chr21:43825000-43850000~~chr21:44475000-44500000,
chr21:43850000-43875000~~chr21:43975000-44000000,
chr21:43850000-43875000~~chr21:44000000-44025000,
chr21:43850000-43875000~~chr21:44075000-44100000,
chr21:43850000-43875000~~chr21:44250000-44275000,
chr21:5125000-5150000~~chr21:43825000-43850000,