Deatailed information for cohesin site CDBP00420802

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  • Basic information
  • CohesinDB ID: CDBP00420802
  • Locus: chr21-43862655-43863537
  • Data sourse: GSE62063, GSE67783, ENCSR153HNT, ENCSR000BKV
  • Cell type: K-562, HSPC, Ramos
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.967
  • Subunit: NIPBL,SA1,Rad21
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 33%, "14_ReprPCWk": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, ZNF561, E4F1, SOX5, PYGO2, PAX8, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZNF597, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, NR2C2, DRAP1, MXI1, RELB, HCFC1R1, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, TET2, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, ZBTB10, SOX11, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, MBD1, STAT5A, IKZF5, ARID2, AFF1, MBD2, ELL2, HMGB1, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, ZSCAN16, WT1, NEUROD1, JUNB, TCF4, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, MITF, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, L3MBTL4, MNT, ZBTB20, LMO1, DPF2, RYBP, IRF4, DDX20, ZNF423, ZNF677, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, ZNF317, ZSCAN21, NONO, SRF, DDX5, NBN, CHD4, ONECUT1, KDM4A, HOMEZ, TSHZ1, FOXP2, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, LDB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, ARNT, BACH1, NFIB, DAXX, ZNF48, PRDM9, ZEB2, HMBOX1, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, KLF9, ZBTB18, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAT2, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, KLF7, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, SMAD4.1D12, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, HIC1, SP4, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, INO80, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, CREBBP, RARA, ZNF384, NFYC, TAF15, ZNF35, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, NCOA1, GTF3C2, ZNF22, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, TCF7, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF613, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, HMGN3, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF274, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, CREB3, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, HINFP, ZNF205, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, ZNF84, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, FEZF1, TFE3, ZNF664, HBP1, IRF1, EHF, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZFX, ZNF335, ZNF534, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, GR, CDK6, ZNF184, PBX4, NRF1, NR2C1, FOS, SUPT5H, CHD1, TGIF2, MED1, CEBPD, MYB, SCRT2, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ASXL1, BRCA1, SP140, HIF1A, BHLHE22, ZNF519, ZNF740, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, PTRF, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): AGPAT3,TRAPPC10,DNMT3L,CSTB,PDXK
  • Function elements
  • Human SNPs: Blood_protein_levels
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 3
  • Related genes and loops
  • Related gene: ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000160218, ENSG00000142182,
  • Related loop: chr21:43175000-43200000~~chr21:43850000-43875000, chr21:43300000-43325000~~chr21:43850000-43875000, chr21:43750000-43775000~~chr21:43850000-43875000, chr21:43850000-43875000~~chr21:43975000-44000000, chr21:43850000-43875000~~chr21:44000000-44025000, chr21:43850000-43875000~~chr21:44075000-44100000, chr21:43850000-43875000~~chr21:44250000-44275000, chr21:43863007-43867607~~chr21:43937376-43940406, chr21:43863838-43866560~~chr21:43974421-43976456, chr21:43863845-43866538~~chr21:43938251-43940531, chr21:43864564-43867617~~chr21:43938189-43940198, chr21:43864603-43867554~~chr21:43938179-43940032, chr21:43864707-43867527~~chr21:43916051-43918979, chr21:43864776-43867606~~chr21:43974787-43976435, chr21:43864816-43867524~~chr21:43937351-43940350, chr21:43864879-43867702~~chr21:43938102-43940319,
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