Deatailed information for cohesin site CDBP00420811

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  • Basic information
  • CohesinDB ID: CDBP00420811
  • Locus: chr21-43878805-43881692
  • Data sourse: GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE105028, GSE121355, GSE131606, GSE25021, ENCSR917QNE, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, ENCSR703TNG, GSE206145, GSE62063, ENCSR000BMY, ENCSR000BTQ, GSE129526, GSE111913, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS
  • Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hela-Kyoto, MB157, RH4, GM2610, GM12878, Ramos, HeLa-S3, RT-112, K-562, Liver, HSPC, HuCC-T1, H9-hESC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 7% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.811
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 51%, "7_Enh": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, PGR, XBP1, PATZ1, FOXA1, RBFOX2, MLL4, ZFHX2, TFAP4, HDGF, ATF3, ZNF362, RUNX3, PRDM1, IKZF3, ZNF273, ZNF189, SMARCE1, PAX5, TP63, SFPQ, CDX2, ZNF629, KLF5, ELF1, TEAD1, ZNF121, KLF6, SNAI2, ETV1, BCLAF1, ZNF217, ESR1, OCA2, CTCF, JUN, SND1, BAF155, TCF12, E2F6, IRF4, RAD51, TEAD4, GTF2F1, PDX1, RBPJ, EED, TFAP2C, JARID2, GLIS1, POU2F2, NANOG, BRD1, ZSCAN5D, MYCN, ZNF263, CTBP1, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, ERG2, ERG, HOXC5, MYC, SMARCA4, FOXP2, RAD21, GRHL3, RXRA, PROX1, NKX2-1, GABPA, APC, XRCC5, STAT3, NKX3-1, NFE2, DNMT3B, NR3C1, ESRRA, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, EBF3, ZHX2, SPI1, KLF17, PCBP1, HDAC2, GATA2, FLI1, HCFC1, MXI1, RELB, NCOA2, ZNF554, PTBP1, RUNX1, SMC1A, BCL6, CBX1, NKX2-2, SIN3A, ZFX, SMAD3, TET2, ERG3, ZNF18, NSD2, PRDM10, CREBBP, ZNF384, RUNX2, GATA4, OSR2, ARNT, PBX4, DAXX, ATF2, ZEB2, PBX3, MAFB, SUPT5H, CHD1, FOS, CDK8, SMARCB1, MED1, CSNK2A1, TEAD3, ZEB1, SCRT2, PIAS1, NR1H2, KLF9, SETDB1, SREBF2, RBM22, MAFK, NIPBL, SP1, BCL11A, HNF4A, USF1, REST, ATF7, ASH2L, PHIP, SMC3, ELL2, STAG1, MLLT1, NFATC3, ZNF394, TRP47, CBFA2T2, MEF2B, PPARG, AGO1, CBX3, CREM, BRF2, PAF1, FOXA2, ZNF600, EBF1, WT1, ZBTB33, CDK9, HOXB13, ZKSCAN1, BCL3, YY1, RELA, JUNB, SP140, ZIC2, HIF1A, TCF4, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, AGO2, PLAG1, CBX2, KLF4, SP7, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, ZNF334, ZSCAN22, MYOD1, EGR2, ELF3, TBX21, BHLHE40, AR, PAX3-FOXO1, ZBTB42, HEXIM1, ZNF366, HSF1, ZBTB26, NCOR1, BRD4, SCRT1, JUND, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): CSTB,PDXK,AGPAT3,DNMT3L
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 12
  • Number of somatic mutations (non-coding): 12
  • Related genes and loops
  • Related gene: ENSG00000160209, ENSG00000160213, ENSG00000160216, ENSG00000142182,
  • Related loop: chr21:43175000-43200000~~chr21:43850000-43875000, chr21:43175000-43200000~~chr21:43875000-43900000, chr21:43300000-43325000~~chr21:43850000-43875000, chr21:43350000-43375000~~chr21:43875000-43900000, chr21:43750000-43775000~~chr21:43850000-43875000, chr21:43750000-43775000~~chr21:43875000-43900000, chr21:43850000-43875000~~chr21:43975000-44000000, chr21:43850000-43875000~~chr21:44000000-44025000, chr21:43850000-43875000~~chr21:44075000-44100000, chr21:43850000-43875000~~chr21:44250000-44275000, chr21:43875000-43900000~~chr21:44250000-44275000,
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