- Basic information
- CohesinDB ID: CDBP00420818
- Locus: chr21-43896892-43898172
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Data sourse: GSE143937, GSE67783, GSE72082, GSE86191, GSE116868, GSE111913, ENCSR879KXD, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE131606, ENCSR748MVX, GSE115602
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hep-G2, MB157, A-549, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
79% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 62%,
"15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: TRIM28, MAF1
- Target gene symbol (double-evidenced CRMs): PDXK,DNMT3L,AGPAT3,CSTB
- Function elements
- Human SNPs: Cystatin-B_levels
- Number of somatic mutations (coding): 18
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160209,
ENSG00000160213,
ENSG00000160216,
ENSG00000142182,
- Related loop:
chr21:43000000-43025000~~chr21:43900000-43925000,
chr21:43175000-43200000~~chr21:43875000-43900000,
chr21:43350000-43375000~~chr21:43875000-43900000,
chr21:43350000-43375000~~chr21:43900000-43925000,
chr21:43750000-43775000~~chr21:43875000-43900000,
chr21:43800000-43825000~~chr21:43900000-43925000,
chr21:43875000-43900000~~chr21:44250000-44275000,
chr21:43900000-43925000~~chr21:44250000-44275000,
chr21:43900000-43925000~~chr21:44425000-44450000,
chr21:43900000-43925000~~chr21:44475000-44500000,
chr21:43900000-43925000~~chr21:45400000-45425000,