- Basic information
- CohesinDB ID: CDBP00420820
- Locus: chr21-43899414-43901125
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Data sourse: GSE67783, GSE86191, GSE72082, GSE206145, ENCSR153HNT
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Cell type: MCF-7, RPE, HCT-116, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
79% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 46%,
"4_Tx": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NCOA2, TRP47, POU2F2, CHD8, TBL1X, MYCN, ZNF263, KDM4C, ZFX, XBP1, ZBTB48, WT1, STAT1, TET2, ZBTB33, DDX5, ZNF770, CDK9, ERG, YY1, RELA, CREBBP, ZNF384, OGG1, ATF3, MYC, THAP1, SP140, GRHL3, RXRA, CBFB, MECOM, STAT3, NCAPH2, TP63, CHD1, CDK8, AGO2, DNMT3B, GATA1, SRSF3, NCOA3, NR2F2, TRIM28, ZEB1, TEAD1, ZNF3, ESR1, ZNF136, GRHL2, EVI1, SETDB1, ZNF334, GABPB1, CTCF, RBM22, SPI1, HNF4A, AR, REST, GATA2, HEXIM1, HSF1, ZBTB26, BRD4, ZNF490, MAZ, HCFC1R1, ZNF280A, SMC3, AATF, STAG1, AHR, EED
- Target gene symbol (double-evidenced CRMs): AGPAT3,COL18A1,DNMT3L,RRP1,TRPM2,CSTB,PDXK,PKNOX1,TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160209,
ENSG00000160213,
ENSG00000160214,
ENSG00000160216,
ENSG00000142182,
ENSG00000142185,
ENSG00000175894,
ENSG00000182871,
- Related loop:
chr21:43000000-43025000~~chr21:43900000-43925000,
chr21:43175000-43200000~~chr21:43875000-43900000,
chr21:43350000-43375000~~chr21:43875000-43900000,
chr21:43350000-43375000~~chr21:43900000-43925000,
chr21:43750000-43775000~~chr21:43875000-43900000,
chr21:43800000-43825000~~chr21:43900000-43925000,
chr21:43875000-43900000~~chr21:44250000-44275000,
chr21:43900000-43925000~~chr21:44250000-44275000,
chr21:43900000-43925000~~chr21:44425000-44450000,
chr21:43900000-43925000~~chr21:44475000-44500000,
chr21:43900000-43925000~~chr21:45400000-45425000,