Deatailed information for cohesin site CDBP00420825

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  • Basic information
  • CohesinDB ID: CDBP00420825
  • Locus: chr21-43911097-43912991
  • Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, GSE111537, GSE25021, ENCSR000EDW, ENCSR917QNE, GSE67783, ENCSR000BKV, GSE86191, GSE76893, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, ENCSR635OSG, GSE55407, ENCSR000BTQ, ENCSR167MTG, ENCSR054FKH, ENCSR153HNT
  • Cell type: MCF-7, H1-hESC, RPE, HCT-116, Hep-G2, THP-1, K-562, Liver, OCI-AML-3, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 7% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.889
  • Subunit: SA1,Rad21,SMC1,SA2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 37%, "8_ZNF/Rpts": 17%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, ZNF426, FOXA1, RXRB, MLL4, KDM3A, HDGF, ZBTB44, IKZF3, PAX5, ZNF320, TEAD1, OCA2, ZNF577, SOX5, RFX3, ZNF555, GATAD2A, NANOG, ZNF263, POU5F1, DUX4, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, RCOR1, DACH1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1R1, RUNX1, CEBPA, NKX2-2, CRY1, TET2, ZNF654, SP5, SMARCC1, PRDM10, ZBTB2, SMARCB1, PIAS1, MBD1, IKZF5, RBM25, NFATC3, CBFA2T2, CBX3, PAF1, WT1, JUNB, ZNF510, ZFP36, MAF1, PLAG1, KLF4, ZBTB6, EGR2, RBM14, ELF3, ARID4B, RXR, HSF1, ZBTB26, SCRT1, ZNF316, FOSL1, XBP1, ZNF101, ATF3, THRB, ZFP64, CBFB, TP63, MITF, JMJD1C, ELF1, SNAI2, KLF10, JUN, CTCF, L3MBTL4, DPF2, IRF4, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZBTB17, ZBTB48, ZNF317, SRF, DDX5, ONECUT1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, ZBTB11, ZNF560, TBL1XR1, GRHL2, SMARCA5, NFIL3, THAP11, LDB1, AFF4, SOX13, ZNF770, ZNF18, ARNT, ZNF48, ZEB2, MAFB, HMGXB4, TEAD3, ZXDB, ZNF680, USF1, SP1, BCL11A, ZNF479, ASH2L, ZNF548, GLIS2, ZNF623, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, MTA3, MAFF, ZNF580, ZKSCAN1, KDM1A, ZNF266, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, CBX2, TP53, ZNF334, NFKB1, ZNF140, PHF5A, KAT8, EGR1, JUND, BRD4, CUX1, SMAD4.1D12, PGR, CBX5, ZNF697, SOX2, PATZ1, TFAP4, SIN3B, MXD4, ZNF189, SMARCE1, KLF6, ESR1, KLF1, TRIM24, U2AF2, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, HNF4G, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, SPI1, HDAC2, ETV5, BCL6, ERG3, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF781, ZNF518A, CBFA2T3, CDK8, ZEB1, ZMYM3, SREBF2, RBM22, MAFK, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, ZNF34, PPARG, TBL1X, ZNF692, RELA, MAX, NR2F1, NEUROG2, KDM5B, TCF7L2, MYOD1, AR, HEXIM1, DMAP1, AHR, HMG20A, ZSCAN5C, SUZ12, ZFHX2, ZNF529, INSM2, NFIC, PRDM12, CDX2, ZNF629, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, BAF155, EP300, E2F1, SMC1, FOXA3, ZNF175, CHD8, MYCN, ID3, GATAD1, ASCL1, ZNF341, EOMES, RAD21, GRHL3, XRCC5, ZNF614, ZNF639, ZNF750, FEZF1, ZNF664, TFE3, HBP1, ZGPAT, ZNF766, MRTFB, ZC3H11A, PTBP1, CBX1, SMC1A, SIRT6, ZFX, SMAD3, NSD2, PRPF4, NOTCH1, RUNX2, CDK6, ZNF184, GR, FOS, SUPT5H, TGIF2, KDM6B, ZNF558, SCRT2, CEBPD, ZNF3, SETDB1, ZBTB7A, POU2F3, TCF3, SKI, FOXA2, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, GATA1, CEBPG, SP7, NR2F2, ZNF213, BHLHE40, NFKBIZ, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): COL18A1,TRPM2,AGPAT3,TSPEAR,PKNOX1,DNMT3L,RRP1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 30
  • Number of somatic mutations (non-coding): 8
  • Related genes and loops
  • Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000142182, ENSG00000142185, ENSG00000175894, ENSG00000182871,
  • Related loop: chr21:43000000-43025000~~chr21:43900000-43925000, chr21:43350000-43375000~~chr21:43900000-43925000, chr21:43800000-43825000~~chr21:43900000-43925000, chr21:43810123-43811942~~chr21:43917618-43918968, chr21:43864707-43867527~~chr21:43916051-43918979, chr21:43900000-43925000~~chr21:44250000-44275000, chr21:43900000-43925000~~chr21:44425000-44450000, chr21:43900000-43925000~~chr21:44475000-44500000, chr21:43900000-43925000~~chr21:45400000-45425000,
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