Deatailed information for cohesin site CDBP00420831

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  • Basic information
  • CohesinDB ID: CDBP00420831
  • Locus: chr21-43927637-43931258
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE105028, GSE25021, GSE131606, GSE115602, ENCSR917QNE, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE206145, ENCSR000ECE, ENCSR000BTQ, GSE129526, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE68388, GSE38411
  • Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Monocytes, MB157, GM12878, RT-112, H9-hESC, IMR-90, K-562, BCBL-1, Liver, HSPC, HuCC-T1, DKO
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 13% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.811
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 79% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 48%, "4_Tx": 18%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, FOXO1, PGR, NME2, XBP1, FOXA1, SUZ12, PBX2, ZFHX2, ZBTB7B, HDGF, ZNF90, ATF3, ZNF362, CTCFL, RUNX3, WDHD1, THAP1, ZNF444, DPF1, SMARCE1, PAX5, TP63, ELF1, TRIM28, TEAD1, ETV1, SNAI2, ZNF217, ESR1, LMO2, HDAC8, CTCF, TCF12, SND1, BAF155, EP300, JUN, MNT, DPF2, PRDM4, TRIM24, E2F4, E2F1, NR5A2, TEAD4, GTF2F1, PDX1, TFAP2C, RBPJ, GLIS1, POU2F2, NANOG, MYCN, ZNF263, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, STAT1, DDX5, NBN, ERG2, TBP, HNF4G, ERG, PBX1, OGG1, MYC, RFX1, RAD21, GRHL3, RXRA, GABPA, APC, STAT3, NKX3-1, IKZF1, RCOR1, NFE2, DNMT3B, VDR, NR3C1, ZNF750, SRSF3, CEBPB, ESRRA, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, GABPB1, ZHX2, SPI1, HDAC2, GATA2, GATAD2B, MXD3, SIX2, FLI1, SMARCA5, NCOA2, PTBP1, ETV5, RUNX1, CBX1, SMC1A, HDAC1, MAFG, BCL6, NKX2-2, SIN3A, ZFX, ZNF770, NFXL1, TET2, ERG3, NSD2, CREBBP, ZXDC, PRPF4, TAF15, RUNX2, ARNT, NFIB, ATF2, PRDM9, SMAD4, CBFA2T3, FOXM1, NR2C1, SUPT5H, FOS, MED1, CSNK2A1, TEAD3, SCRT2, ZMYM3, PIAS1, ZNF3, C11orf30, RBM22, MAFK, SP1, TFAP2A, BCL11A, HNF4A, REST, ARID1A, RBM25, ASH2L, HNRNPLL, CTBP2, BCOR, FOXP1, MBD2, TCF3, AATF, SMC3, NCOR2, STAG1, MLLT1, TRP47, CBFA2T2, MEF2B, CBX3, FOXA2, MTA3, EBF1, PAF1, AGO1, ZNF600, CREM, GTF2B, WT1, MAFF, ZBTB33, CDK9, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, AHR, SP140, ZFP36, ZIC2, HIF1A, GATA3, TAL1, MAX, NRIP1, GATA1, ZNF143, AGO2, MTA1, PLAG1, KLF4, NCOA3, NR2F2, ZNF768, NR2F1, KDM5B, ZNF687, PKNOX1, ZNF334, EGR2, PHOX2B, TBX21, BHLHE40, AR, ZNF579, ZBTB40, HEXIM1, RB1, TFIIIC, HSF1, JUND, BRD4, MAZ, ZNF24, ADNP, ZNF316
  • Target gene symbol (double-evidenced CRMs): PDXK,TRAPPC10,RRP1B,AGPAT3,RRP1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 84
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000160208, ENSG00000160209, ENSG00000160214, ENSG00000160216, ENSG00000160218,
  • Related loop: chr21:43000000-43025000~~chr21:43900000-43925000, chr21:43350000-43375000~~chr21:43900000-43925000, chr21:43350000-43375000~~chr21:43925000-43950000, chr21:43700000-43725000~~chr21:43925000-43950000, chr21:43800000-43825000~~chr21:43900000-43925000, chr21:43800000-43825000~~chr21:43925000-43950000, chr21:43810035-43812029~~chr21:43928620-43930391, chr21:43825000-43850000~~chr21:43925000-43950000, chr21:43900000-43925000~~chr21:44250000-44275000, chr21:43900000-43925000~~chr21:44425000-44450000, chr21:43900000-43925000~~chr21:44475000-44500000, chr21:43900000-43925000~~chr21:45400000-45425000, chr21:43925000-43950000~~chr21:44025000-44050000,
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