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Basic information

CohesinDB ID: CDBP00420838

Locus: chr21-43953873-43955291

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 56%, "15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, FOXA1, MLL4, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, ZNF121, LMO2, OCA2, E4F1, ZNF157, PAX8, ZNF407, ZNF211, ZNF410, ZNF528, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, ZNF488, ERG, ZNF597, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, ZNF398, RCOR1, NFRKB, CEBPB, HNRNPL, CREB1, ZHX2, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, ZNF785, RELB, RUNX1, CEBPA, HDAC1, ZNF707, CRY1, NKX2-2, TET2, TBX3, ZNF473, MCM2, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZNF622, SOX11, ATF2, FOXM1, SMARCB1, SMAD1, STAT5A, GSPT2, ARID2, AFF1, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, PAF1, NFATC1, ZSCAN16, WT1, JUNB, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, BATF, ZSCAN26, PLAG1, BCL11B, ZNF544, IRF5, MED, BCL6B, EGR2, RBM14, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ZNF316, ZNF621, XBP1, TSC22D4, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, CDC5L, MAF, JMJD1C, ELF1, RBM39, ZIK1, CTCF, JUN, ZBTB20, MNT, DPF2, IRF4, ZNF776, ZNF280A, TFAP2C, RBPJ, YBX1, ZNF239, ZNF317, MTA2, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, PHB2, CHD4, PBX1, ONECUT1, TRIP13, ZNF2, FOXP2, RXRA, NKX3-1, NR3C1, ESRRA, KMT2A, ARHGAP35, GRHL2, SSRP1, ZNF146, ZSCAN29, SMARCA5, CC2D1A, ZBTB24, ZNF747, POU4F2, ZNF18, ARNT, DAXX, BACH1, NFIB, ZNF48, ZEB2, ETV6, PBX3, NCAPH2, TEAD3, KLF9, BCL11A, SP1, ATF7, GLIS2, SMC3, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, MAFF, BCL3, ZKSCAN1, KDM1A, KAT2B, ZNF266, ZNF155, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF645, NFKB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, ZSCAN23, PGR, PATZ1, BMI1, CHD7, ZNF444, ATF4, SMARCE1, MCM7, ZNF217, ESR1, TP73, SND1, KLF1, TRIM24, GTF2F1, GLIS1, POU2F2, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ERG2, OGG1, ETS1, MYC, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, SPI1, ZNF202, PCBP1, HDAC2, GATAD2B, ZNF554, SALL2, BCL6, ERG3, NFXL1, CREBBP, RARA, ZNF169, TAF15, ZNF280C, CBFA2T3, CDK8, ZMYM3, NCOA1, RBM22, MAFK, REST, HNRNPLL, BCOR, AATF, NCOR2, PPARG, TBL1X, GTF2B, ZNF662, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, NR2F1, ZNF791, KDM5B, NEUROG2, PKNOX1, ZNF547, MYOD1, T, AR, ZNF324, HEXIM1, AHR, MBD3, ZNF391, SUZ12, ZFHX2, ZNF274, INSM2, NFIC, ZBTB5, CTCFL, THRAP3, TRIM28, BCLAF1, ETV1, TCF12, EP300, GLI4, RAD51, ZNF512B, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ARID3A, ZNF300, AEBP2, ZNF585B, MIER1, GRHL3, XRCC5, NFE2, ZNF639, ARNTL, HES1, ZNF664, IRF1, SREBF1, ZIM3, CBX1, SMC1A, ZFX, SMAD3, NSD2, BRD9, RUNX2, GATA4, OSR2, ZNF184, SUPT5H, FOS, MED1, KDM6B, MYB, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, TCF3, SALL1, NCOA4, FOXA2, RBBP5, E2F8, ZNF600, ZBTB33, HOXB13, YY1, ZNF148, ZNF521, SP140, HIF1A, OTX2, GATA1, NCOA3, NR2F2, ZNF354C, ZNF687, ZNF837, BHLHE40, TAF1, ZBTB40, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): DNMT3L,RRP1,UBE2G2,CFAP410,PFKL,TRAPPC10,PDE9A,AGPAT3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 103

Number of somatic mutations (non-coding): 17

Related genes and loops

Related gene: ENSG00000160191, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000184787,

eachgene

Deatailed information for cohesin site CDBP00420838