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Basic information

CohesinDB ID: CDBP00420846

Locus: chr21-43970557-43970863

Data sourse: GSE67783, GSE86191

Cell type: HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 62%, "5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, ZNF121, OCA2, MED26, E4F1, ZNF157, SOX5, PAX8, ZNF407, E2F4, DEK, ZNF410, ZNF528, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ZNF563, SAP130, ERG, PAX6, ZBTB21, EZH1, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, RCOR1, NR2F6, DACH1, NFRKB, CEBPB, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, SIX2, FLI1, HCFC1, ZNF785, MXI1, DRAP1, RELB, RUNX1, HDAC1, NKX2-2, ZNF707, CRY1, REPIN1, TET2, ZNF473, ZNF654, TRIM22, SMARCC1, PRDM10, ZBTB2, ZBTB10, ATF2, SNIP1, FOXM1, SMARCB1, PIAS1, SMAD1, STAT5A, GSPT2, IKZF5, ARID2, ZNF605, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, NFATC1, PAF1, SS18, ZSCAN16, WT1, NEUROD1, ZFP36, ZNF311, BATF, MAF1, SPIB, PLAG1, ZFP69B, KLF4, ZNF544, BCL6B, EGR2, ELF3, ARID4B, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF621, XBP1, PBX2, ATF3, RUNX3, CBFB, TP63, ZSCAN4, MITF, CDC5L, JMJD1C, MAF, ELF1, SNAI2, ZNF624, ZIK1, CTCF, JUN, MNT, ZBTB20, DPF2, IRF4, DDX20, ZNF423, ZNF776, ZNF280A, TFAP2C, RBPJ, YBX1, ZNF239, ZSCAN21, ZNF317, MTA2, ZBTB48, ZBTB17, NONO, SRF, DDX5, NBN, PHB2, TRIP13, ZNF2, HOMEZ, FOXP2, KDM4A, RXRA, PRDM14, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, TBL1XR1, KLF8, ARHGAP35, GRHL2, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, ZNF18, NFIB, BACH1, ARNT, DAXX, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ETV6, HMGXB4, TEAD3, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, ZNF548, PCGF2, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF645, ZNF334, PHF5A, BRD2, KAT8, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, PRDM2, CUX1, ZSCAN23, CBX5, PGR, SOX2, PATZ1, BMI1, SETX, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, ZNF524, KLF1, ZNF695, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ASH1L, ZSCAN5A, HIC1, HOXC5, OGG1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, ZNF436, SPI1, HDAC2, GATAD2B, ZNF76, NCOA2, SALL2, ETV5, BCL6, SIN3A, ERG3, NFXL1, RARA, ZNF384, CREBBP, ZNF35, TAF15, ZNF169, ZNF280C, SMAD4, CBFA2T3, CDK8, ZEB1, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, ZNF692, GTF2B, ZNF662, ZNF574, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, KDM5B, PKNOX1, ZNF547, MYOD1, AR, ZNF324, HEXIM1, AHR, ZNF391, SUZ12, ZFHX2, ZNF90, INSM2, NFIC, ZBTB5, CTCFL, PRDM1, ZNF629, KLF5, THRAP3, TRIM28, BCLAF1, ETV1, USF2, TCF12, EP300, BAF155, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, GATAD1, ARID3A, MIER1, EOMES, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, ARNTL, ZNF750, JMJD6, TFE3, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, TWIST1, NSD2, IRF2, NOTCH1, BRD9, RUNX2, GATA4, OSR2, ZNF184, PBX4, SUPT5H, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SALL1, PAX7, NCOA4, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF837, BHLHE40, NFKBIZ, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PFKL,AGPAT3,TRAPPC10,DNMT3L,CFAP410,PDE9A,RRP1,UBE2G2

Function elements

Human SNPs: Adverse_response_to_drug

Number of somatic mutations (coding): 198

Number of somatic mutations (non-coding): 33

Related genes and loops

Related gene: ENSG00000160191, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000184787,

eachgene

Deatailed information for cohesin site CDBP00420846