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Basic information

CohesinDB ID: CDBP00420848

Locus: chr21-43978988-43982273

Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE131606, GSE108869, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, GSE116344, GSE145327, GSE94872, ENCSR895JMI, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000EHX, ENCSR495WGO, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS

Cell type: RH4, GM10847, GM19240, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, GM19238, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 24% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.556

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 45%, "5_TxWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, TRIM25, E2F7, HMGN3, NME2, SOX2, XBP1, PATZ1, FOXA1, PBX2, ZFHX2, KDM3A, HDGF, ZNF90, ATF3, ZNF362, ZBTB44, PRDM1, CHD7, CBFB, PAX5, TP63, ZSCAN4, HDAC3, ZNF736, MAF, KLF5, ELF1, BCLAF1, RBM39, ETV1, SNAI2, KLF6, LMO2, ESR1, OCA2, CTCF, JUN, BAF155, KLF1, MNT, SOX5, ZNF641, TRIM24, E2F4, DEK, E2F1, ZNF528, FOXA3, TFAP2C, RBPJ, GLIS1, NANOG, POU2F2, BRD1, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, ID3, ZSCAN5D, ERF, ZNF317, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, TBP, ERG, HOXC5, ASCL1, OGG1, MYC, SMARCA4, RFX1, KDM4A, RAD21, FOXP2, GRHL3, TOP1, KLF12, RXRA, ZKSCAN2, GABPA, STAT3, APC, XRCC5, NKX3-1, PRDM14, IKZF1, NFE2, DNMT3B, NR2F6, VDR, NR3C1, CEBPB, SRSF3, HNRNPL, CREB1, EZH2, KLF8, GRHL2, EBF3, GABPB1, ZHX2, SPI1, HDAC2, GATA2, SSRP1, GATAD2B, MXD3, SIX2, FLI1, ZGPAT, HCFC1R1, PTBP1, ETV5, RUNX1, SMC1A, BCL6, CEBPA, SIRT6, FIP1L1, ZFX, SIN3A, TET2, ERG3, PRDM10, ZBTB2, ZNF384, NFYC, RARA, TAF15, RUNX2, GATA4, PBX4, DAXX, BACH1, ARNT, NRF1, ZNF48, PRDM9, SMAD4, ATF2, PBX3, FOXM1, SP2, SUPT5H, CDK8, FOS, HMGXB4, SMARCB1, MED1, TEAD3, PML, ZNF558, KDM6B, SCRT2, PIAS1, ZEB1, SUPT16H, ZNF3, SREBF2, STAT5A, RBM22, SP1, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, CCNT2, ZNF479, ASH2L, HNRNPLL, CTBP2, TCF3, FOXP1, BCOR, AATF, SMC3, STAG1, MLLT1, NFATC3, TRP47, CBFA2T2, FOXA2, AGO1, MTA3, RBBP5, PAF1, E2F8, ZNF600, NFATC1, GTF2B, WT1, ZBED1, EBF1, ZBTB33, TCF7, ZNF823, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, ZNF282, SP140, ZIC2, HIF1A, PCGF1, TCF4, GATA3, KLF15, MAF1, MAX, NRIP1, SPIB, AGO2, GATA1, ZNF143, PLAG1, TLE3, CBX2, CEBPG, SP7, GFI1B, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, MYOD1, EGR2, ARID4B, AR, BHLHE40, TAF1, RXR, ZNF366, HEXIM1, EGR1, HSF1, ZBTB26, MYNN, BRD4, JUND, SCRT1, ILF3, CLOCK, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): CFAP410,AGPAT3,PFKL,PKNOX1,DNMT3L,RRP1,TRAPPC10

Function elements

Human SNPs: .

Number of somatic mutations (coding): 222

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226,

eachgene

Deatailed information for cohesin site CDBP00420848