- Basic information
- CohesinDB ID: CDBP00420850
- Locus: chr21-43984827-43986234
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Data sourse: GSE118494, ENCSR338DUC, GSE67783, GSE72082, GSE86191, ENCSR000BLS, GSE105028, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, GSE131606, GSE50893
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Cell type: RPE, GM2630, Fibroblast, HCT-116, Hep-G2, GM2610, DKO, IMR-90, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
79% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 38%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, TRIM25, E2F7, HMGN3, NME2, SOX2, XBP1, PATZ1, FOXA1, PBX2, ZFHX2, KDM3A, HDGF, ZNF90, ATF3, ZNF362, ZBTB44, PRDM1, CHD7, CBFB, PAX5, TP63, ZSCAN4, HDAC3, ZNF736, MAF, KLF5, ELF1, BCLAF1, RBM39, ETV1, SNAI2, KLF6, LMO2, ESR1, OCA2, CTCF, JUN, BAF155, KLF1, MNT, SOX5, ZNF641, TRIM24, E2F4, DEK, E2F1, ZNF528, FOXA3, TFAP2C, RBPJ, GLIS1, NANOG, POU2F2, BRD1, CHD8, MYCN, POU5F1, ZNF263, RUNX1T1, ID3, ZSCAN5D, ERF, ZNF317, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, TBP, ERG, HOXC5, ASCL1, OGG1, MYC, SMARCA4, RFX1, KDM4A, RAD21, FOXP2, GRHL3, TOP1, KLF12, RXRA, ZKSCAN2, GABPA, STAT3, APC, XRCC5, NKX3-1, PRDM14, IKZF1, NFE2, DNMT3B, NR2F6, VDR, NR3C1, CEBPB, SRSF3, HNRNPL, CREB1, EZH2, KLF8, GRHL2, EBF3, GABPB1, ZHX2, SPI1, HDAC2, GATA2, SSRP1, GATAD2B, MXD3, SIX2, FLI1, ZGPAT, HCFC1R1, PTBP1, ETV5, RUNX1, SMC1A, BCL6, CEBPA, SIRT6, FIP1L1, ZFX, SIN3A, TET2, ERG3, PRDM10, ZBTB2, ZNF384, NFYC, RARA, TAF15, RUNX2, GATA4, PBX4, DAXX, BACH1, ARNT, NRF1, ZNF48, PRDM9, SMAD4, ATF2, PBX3, FOXM1, SP2, SUPT5H, CDK8, FOS, HMGXB4, SMARCB1, MED1, TEAD3, PML, ZNF558, KDM6B, SCRT2, PIAS1, ZEB1, SUPT16H, ZNF3, SREBF2, STAT5A, RBM22, SP1, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, CCNT2, ZNF479, ASH2L, HNRNPLL, CTBP2, TCF3, FOXP1, BCOR, AATF, SMC3, STAG1, MLLT1, NFATC3, TRP47, CBFA2T2, FOXA2, AGO1, MTA3, RBBP5, PAF1, E2F8, ZNF600, NFATC1, GTF2B, WT1, ZBED1, EBF1, ZBTB33, TCF7, ZNF823, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, BRG1, ZNF282, SP140, ZIC2, HIF1A, PCGF1, TCF4, GATA3, KLF15, MAF1, MAX, NRIP1, SPIB, AGO2, GATA1, ZNF143, PLAG1, TLE3, CBX2, CEBPG, SP7, GFI1B, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, MYOD1, EGR2, ARID4B, AR, BHLHE40, TAF1, RXR, ZNF366, HEXIM1, EGR1, HSF1, ZBTB26, MYNN, BRD4, JUND, SCRT1, ILF3, CLOCK, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): PKNOX1,RRP1,TRAPPC10,DNMT3L,PFKL,AGPAT3,CFAP410
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 22
- Number of somatic mutations (non-coding): 11
- Related genes and loops
- Related gene:
ENSG00000160199,
ENSG00000160214,
ENSG00000160216,
ENSG00000160218,
ENSG00000142182,
ENSG00000141959,
ENSG00000160226,
- Related loop:
chr21:43000000-43025000~~chr21:43975000-44000000,
chr21:43175000-43200000~~chr21:43975000-44000000,
chr21:43300000-43325000~~chr21:43975000-44000000,
chr21:43350000-43375000~~chr21:43975000-44000000,
chr21:43800000-43825000~~chr21:43975000-44000000,
chr21:43850000-43875000~~chr21:43975000-44000000,
chr21:43975000-44000000~~chr21:44075000-44100000,
chr21:43975000-44000000~~chr21:44250000-44275000,
chr21:43975000-44000000~~chr21:44275000-44300000,
chr21:43975000-44000000~~chr21:44300000-44325000,
chr21:43979276-43980550~~chr21:44266775-44268941,