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Basic information

CohesinDB ID: CDBP00420853

Locus: chr21-43991128-43996175

Data sourse: ENCSR167MTG, ENCSR338DUC, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE116868, GSE111913, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE83726, GSE25021, GSE165895

Cell type: MCF-7, RPE, Fibroblast, HCT-116, RH4, Hep-G2, MB157, RT-112, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 79% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 33%, "14_ReprPCWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, XBP1, PATZ1, HLF, SUZ12, ZFHX2, KDM3A, TFAP4, ATF3, THRB, THAP1, ZBTB5, CBFB, MECOM, PAX5, TP63, ELF1, TRIM28, TEAD1, RBM39, SNAI2, ESR1, OCA2, HDAC8, USF2, CTCF, JUN, L3MBTL4, MNT, SOX5, E2F6, ZNF528, FOXA3, GATAD2A, GTF2F1, RBPJ, TFAP2C, CHD8, BRD1, ZSCAN5D, ZNF263, MYCN, KDM4C, CTBP1, ZBTB17, ZBTB48, ZSCAN5A, STAT1, GATAD1, SAP130, ERG2, HNF4G, ERG, OGG1, MYC, SMARCA4, RAD21, GRHL3, RXRA, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, DNMT3B, NR2F6, NR3C1, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, TFE3, HDAC2, MXD3, ZNF146, FLI1, DRAP1, NFIL3, NCOA2, ATF1, ETV5, PTBP1, RUNX1, THAP11, BCL6, CEBPA, ZNF335, ZFX, SOX13, FIP1L1, ZNF770, TET2, ERG3, PRDM10, RARA, RUNX2, ARNT, NRF1, ATF2, ZNF48, SMAD4, PRDM9, NCAPH2, SP2, CHD1, HMGXB4, TEAD3, ZEB1, KDM6B, CEBPD, ZNF3, SREBF2, USF1, BCL11A, HNF4A, IKZF5, REST, ZBTB7A, HNRNPLL, TCF3, AATF, SMC3, STAG1, ETV4, TRP47, KLF13, PPARG, AGO1, FOXA2, CREM, ZNF600, MIER2, ZNF692, WT1, MAFF, ZBTB33, CDK9, ZNF580, KDM1A, YY1, RELA, SP140, HIF1A, MAF1, MAX, GATA1, AGO2, PLAG1, CBX2, CEBPG, NCOA3, NR2F2, NR2F1, KDM5B, EGR2, ELF3, BRD2, KAT8, BHLHE40, ARID4B, AR, TAF1, RXR, HEXIM1, RB1, TFIIIC, HSF1, ZBTB26, JUND, BRD4, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): PFKL,RRP1,DNMT3L,TRAPPC10,CFAP410,PKNOX1,AGPAT3

Function elements

Human SNPs: Estimated_glomerular_filtration_rate_in_diabetes

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 39

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226,

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Deatailed information for cohesin site CDBP00420853