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Basic information

CohesinDB ID: CDBP00420856

Locus: chr21-43999790-44003430

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT

Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 49%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, XBP1, SUZ12, LEO1, PBX2, ZFHX2, ATF3, PRDM1, MECOM, TP63, MITF, TRIM28, NFE2L2, ESR1, OCA2, HDAC8, USF2, CTCF, GATA6, DPF2, SOX4, EED, POU2F2, BRD1, MYCN, ZNF263, ZBTB48, ZSCAN5A, ERG2, SP4, ERG, OGG1, MYC, GRHL3, PRDM14, NFE2, DNMT3B, NR3C1, EZH2, SPI1, MXD3, FLI1, RUNX1, MAFG, SMC1A, ZFX, ZNF534, POU4F2, ZNF770, CBX8, TET2, ERG3, PRDM10, RUNX2, ARNT, CHD1, SMARCB1, CDK8, KDM6B, ZNF3, ZBTB7A, HNRNPLL, AATF, SMC3, STAG1, CBFA2T2, ZNF316, TBL1X, EBF1, WT1, YY1, RELA, SP140, ZFP36, MAX, ZNF143, PLAG1, NCOA3, NEUROG2, NFKB1, AR, HSF1, BRD4, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): TRAPPC10,RRP1,AGPAT3,CSTB,PKNOX1,CFAP410,DNMT3L,TSPEAR,PDXK,PFKL,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 26

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420856