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Basic information

CohesinDB ID: CDBP00420857

Locus: chr21-44003656-44007434

Data sourse: ENCSR230ZWH, ENCSR501LQA, ENCSR000BLY, ENCSR000ECS, ENCSR330ELC, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR217ELF, ENCSR853VWZ, ENCSR956LGB, ENCSR000HPG, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, ENCSR748MVX

Cell type: RPE, Fibroblast, HCT-116, A-549, GM12891, HeLa-S3, IMR-90, SK-N-SH, K-562, Liver, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 40%, "7_Enh": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SOX2, XBP1, FOXA1, PBX2, ZFHX2, NFIC, CHD7, PAX5, MITF, ZNF736, ZNF467, TEAD1, ZNF121, ETV1, RBM39, NFE2L2, RCOR2, ESR1, USF2, CTCF, TCF12, JUN, EP300, DPF2, SOX4, RFX5, E2F1, TEAD4, GTF2F1, TFAP2C, POU2F2, CHD8, BRD1, MYCN, POU5F1, ZBTB17, ZBTB48, STAT1, SAP130, ERG2, TBP, HNF4G, ERG, HOXC5, ETS1, ONECUT1, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, VDR, NR3C1, CEBPB, CREB1, BMPR1A, GRHL2, EBF3, ZHX2, ZNF664, EHF, HDAC2, GATA2, MXD3, SMARCA5, NFIL3, ETV5, RUNX1, CEBPA, SIN3A, ZFX, POU4F2, SMAD3, ZNF770, ERG3, ZNF549, PRDM10, SMARCC1, ZNF384, RUNX2, SMAD2, GR, ARNT, PBX4, DAXX, SMAD4, PBX3, FOS, CHD1, MED1, TEAD3, CEBPD, SCRT2, ZMYM3, SUPT16H, ZNF3, MAFK, BCL11A, SP1, USF1, HNF4A, SMAD2-3, IKZF5, REST, BCOR, SMC3, STAG1, SKI, FOXA2, ZNF600, WT1, ZNF580, HOXB13, KDM1A, RELA, JUNB, AHR, SP140, HIF1A, GATA3, TAL1, MAX, NCOA3, NR2F2, TP53, PKNOX1, EGR2, BRD2, BHLHE40, AR, NFKBIZ, TAF1, ZBTB42, EGR1, HSF1, ZBTB26, SCRT1, BRD4, JUND, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): AGPAT3,PDXK,CSTB,TRAPPC10,DNMT3L,CFAP410,PFKL,RRP1,TSPEAR,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 27

Related genes and loops

Related gene: ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

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Deatailed information for cohesin site CDBP00420857