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Basic information

CohesinDB ID: CDBP00420861

Locus: chr21-44016585-44017233

Data sourse: GSE206145-NatGen2015, GSE67783, ENCSR153HNT, ENCSR879KXD

Cell type: K-562, Fibroblast, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 46%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, HDAC8, ZNF561, E4F1, ARID5B, ZNF75A, SOX5, PAX8, ZNF407, DEK, E2F4, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, TOP2A, CTBP1, ERF, ZMYND11, DUX4, STAT1, SAP130, ERG, PAX6, ZBTB21, ZNF597, ZBTB8A, NFKB2, EZH1, SMARCA4, RFX1, TOP1, DNMT1, FOXK2, ZNF398, RCOR1, NR2F6, CD74, NFRKB, CEBPB, HNRNPL, RBM34, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, HCFC1, MXI1, NR2C2, RELB, EP400, RUVBL2, RUNX1, ZMYM2, HDAC1, CEBPA, NKX2-2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ELK1, ZBTB10, ATF2, SATB1, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, C11orf30, EVI1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, AFF1, MBD2, THRA, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, NFATC1, PAF1, SS18, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ZNF596, HNRNPK, THRB, ATF3, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, ZNF273, TP63, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, L3MBTL4, ZBTB20, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF677, PDX1, RBPJ, TFAP2C, MLX, YBX1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, MTA2, NONO, SRF, DDX5, NBN, PHB2, ZNF329, KDM4A, HOMEZ, FOXP2, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, ZNF585A, LDB1, SOX13, AFF4, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, NFYA, HMBOX1, ETV6, NCAPH2, MAFB, PBX3, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, KLF7, ZKSCAN1, KDM1A, BCL3, ZNF441, KAT2B, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, CBX5, FANCL, SOX2, PATZ1, LEO1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, SND1, KLF1, SOX9, SOX4, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ZNF671, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, GFI1, IKZF1, INO80, ZNF343, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, ZNF182, GATAD2B, NCOA2, ZNF76, NFYB, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, CREBBP, ZNF384, ZNF35, TAF15, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, SREBF2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, YY2, FOXO3, ZNF318, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, ZNF547, MYOD1, AR, PAX3-FOXO1, KMT2D, ZBTB16, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, MBD3, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, LYL1, ZNF90, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, CDX2, ZNF629, ZNF506, THRAP3, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, SOX6, CREB3, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ZNF205, GATAD1, GMEB2, ARID3A, USP7, MIER1, ZNF341, ASCL1, RAD21, GRHL3, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, FEZF1, HES1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, ZIM3, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, OSR2, GR, ZNF184, CDK6, NRF1, NR2C1, FOS, SUPT5H, CHD1, MED1, CEBPD, MYB, KDM6B, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, PAX7, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PDXK,TRPM2,PFKL,DNMT3L,CFAP410,CSTB,AGPAT3,TSPEAR,RRP1,TRAPPC10

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160209, ENSG00000160213, ENSG00000160214, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894,

eachgene

Deatailed information for cohesin site CDBP00420861