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Basic information

CohesinDB ID: CDBP00420868

Locus: chr21-44027505-44027848

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 69%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, HDGF, ZBTB44, IKZF3, PAX5, ZNF320, TEAD1, ZNF121, LMO2, HDAC8, ZNF561, E4F1, E2F4, ZNF410, ZNF528, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, BRD3, CTBP1, DUX4, STAT1, ERG, ZBTB21, ZBTB8A, SMARCA4, FOXK2, ZNF398, RCOR1, DACH1, NFRKB, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, KLF17, GATA2, FLI1, HCFC1, MXI1, NR2C2, RELB, EP400, RUNX1, HDAC1, NKX2-2, CEBPA, TRIM22, PRDM10, ZBTB2, ATF2, SNIP1, FOXM1, SMARCB1, GMEB1, C11orf30, EVI1, GSPT2, AFF1, MBD2, NFATC3, CBFA2T2, CBX3, CREM, CHD2, PAF1, ZSCAN16, WT1, NEUROD1, JUNB, MCM3, BATF, ZFP69B, BCL11B, EGR2, RXR, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, PBX2, ATF3, ZFP64, RUNX3, ZSCAN4, MITF, BACH2, CDC5L, JMJD1C, MAF, ELF1, RBM39, JUN, CTCF, ZBTB20, LMO1, MNT, DPF2, ZNF423, DDX20, TFAP2C, ZSCAN21, ZBTB17, ZBTB48, ZNF317, MTA2, NONO, SRF, DDX5, NBN, TSHZ1, HOMEZ, RXRA, LEF1, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, GRHL2, ZSCAN29, SMARCA5, NFIL3, CC2D1A, POU4F2, ZMIZ1, ZNF18, ARNT, BACH1, PRDM9, HMBOX1, ZEB2, MAFB, TEAD3, ZXDB, USF1, BCL11A, ATF7, GLIS2, PRDM6, SMC3, STAG1, MLLT1, MTA3, EBF1, MAFF, ESR2, KLF7, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, ZNF334, NFKB1, PHOX2B, BRD2, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, SOX2, PATZ1, LEO1, UBTF, CHD7, ATF4, ZNF189, SMARCE1, MZF1, NFE2L2, ESR1, ZNF524, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ERG2, TBP, HOXC5, SMARCC2, MYC, ARID1B, GABPA, STAT3, IKZF1, EZH2, SPI1, HDAC2, ZNF182, GATAD2B, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, ZNF35, ZNF384, CBFA2T3, CDK8, ZNF264, NCOA1, SREBF2, RBM22, MAFK, NR4A1, REST, HOXA9, BCOR, ZNF34, PPARG, TBL1X, ZNF692, ZNF30, ZNF574, ZNF318, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, PKNOX1, MYOD1, AR, PAX3-FOXO1, ZNF324, AHR, FOSL2, ZSCAN5C, MEIS2, ZFHX2, INSM2, NFIC, PRDM1, MECOM, ZNF736, ZNF629, TRIM28, ZFP91, TCF12, BAF155, EP300, CREB3, SOX6, RAD51, E2F1, TEAD4, EHMT2, EED, CHD8, MYCN, RUNX1T1, ID3, ARID3A, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, ZNF664, IRF1, ZNF766, MRTFB, ATF1, SMC1A, MAFG, ZFX, NSD2, PRPF4, BRD9, RUNX2, ZSCAN30, OSR2, ZNF184, PBX4, NR2C1, CHD1, FOS, SUPT5H, MED1, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, ZBTB7A, PHIP, TCF3, FOXA2, RBBP5, E2F8, ZNF600, ZBTB33, HOXB13, YY1, ZNF148, SP140, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, ZBTB40, ZBTB42, MYNN, MAZ, MEF2D, ZNF24

Target gene symbol (double-evidenced CRMs): TRAPPC10,LRRC3,PFKL,DNMT3L,CFAP410,PKNOX1,AGPAT3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000160233,

eachgene

Deatailed information for cohesin site CDBP00420868