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Basic information

CohesinDB ID: CDBP00420878

Locus: chr21-44041439-44041931

Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 62% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 94%, "4_Tx": 5%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SOX2, XBP1, FOXA1, LEO1, HDGF, ATF3, ZNF362, PRDM1, PAX5, TRIM28, RBM39, SAP30, ESR1, CTCF, TCF12, E4F1, DPF2, E2F6, SOX6, TEAD4, EED, CHD8, ZSCAN5D, RUNX1T1, CTBP1, MTA2, DUX4, ZBTB48, STAT1, NBN, ZNF300, ERG, PBX1, MYC, SMARCA4, RAD21, GRHL3, GABPA, IKZF1, RCOR1, NR3C1, KMT2A, EZH2, SPI1, HDAC2, ZNF182, FLI1, SMARCA5, ZIM3, SMC1A, ZFX, SMAD3, TRIM22, ZBTB2, ZNF384, NOTCH1, CDK6, GATA4, ETV6, SUPT5H, CDK8, FOS, MED1, MYB, ZNF3, ZNF22, RBM22, BCL11A, NKX2-5, REST, TCF3, MLLT1, PPARG, TBL1X, MTA3, EBF1, ZNF600, ZSCAN16, WT1, ZKSCAN1, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, MAX, ZNF143, GATA1, PLAG1, NCOA3, KDM5B, TP53, PHOX2B, HSF1, RNF2, MYNN, BRD4, ILF3, JUND, MAZ, ZZZ3

Target gene symbol (double-evidenced CRMs): PKNOX1,CFAP410,AGPAT3,TRAPPC10,PFKL,LRRC3,DNMT3L

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000160199, ENSG00000160216, ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000160233,

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Deatailed information for cohesin site CDBP00420878